Novel pH-sensitive hydrogels with adjustable swelling kinetics
Novel pH-sensitive hydrogels with adjustable swelling kinetics
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DOI：
10.1016/s0142-9612(98)00023-4
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发表时间：
1998-06-01
期刊：
影响因子：
14
通讯作者：
Kopecek, J
中科院分区：
文献类型：
--
作者：
Akala, EO;Kopecková, P;Kopecek, J
以N，N-二甲基丙烯酰胺、叔丁基二甲基丙烯酰胺和N，N-二甲基丙烯酰胺为单体，通过共聚反应合成了pH敏感性水凝胶。丁基丙烯酰胺、丙烯酸、4，4 ′-二（甲基丙烯酰氨基）偶氮苯和N-烷酰基、O-甲基丙烯酰羟胺。链烷酰基（丙酰基、己酰基和月桂酰基）的长度（以及因此的疏水性）及其在水凝胶中的含量对溶胀动力学的影响进行了研究。pH值从酸性变为中性后，N-烷酰基、O-酰基羟胺部分水解。侧链水解的速率取决于网络结构中烷基的长度和可水解共聚单体的含量。此外，通过合成含有两种类型的交联剂（一种可水解，另一种可酶降解）的水凝胶，将溶胀动力学的化学控制与溶胀动力学的生物物理控制相结合。交联聚合物的溶胀动力学进行了比较与N-烷酰基，O-甲基丙烯酰基羟胺部分的水解动力学纳入线性可溶性共聚物的类似结构。(C)1998爱思唯尔科技有限公司版权所有。
Novel pH-sensitive hydrogels were synthesized by copolymerization of N,N-dimethylacrylamide, tert.-butylacrylamide, acrylic acid, 4,4'-di(methacryloylamino)azobenzene, and N-alkanoyl, O-methacryloylhydroxylamines. The influence of the length (and consequently hydrophobicity) of the alkanoyl (propionyl, hexanoyl, and lauroyl), and its content in the hydrogel on the kinetics of swelling were investigated. Upon change in the pH from acidic to neutral, N-alkanoyl, O-acylhydroxylamine moieties were hydrolyzed. The rate of side-chain hydrolysis was dependent on the length of the alkyl and the content of the hydrolyzable comonomer in the network structure. Further, chemical control of kinetics of swelling was coupled to biophysical control of kinetics of swelling by synthesizing hydrogels containing two types of cross-linking agents, one hydrolyzable, the other enzymatically degradable. The kinetics of swelling of cross-linked polymers was compared with the kinetics of hydrolysis of N-alkanoyl, O-methacryloylhydroxylamine moieties incorporated into linear soluble copolymers of similar structures. (C) 1998 Elsevier Science Ltd. All rights reserved.