Prenatal exposure to phthalate esters and PAHs and birth outcomes
Prenatal exposure to phthalate esters and PAHs and birth outcomes
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DOI：
10.1016/j.envint.2010.05.003
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发表时间：
2010-10-01
影响因子：
11.8
通讯作者：
Shiraishi, Hiroaki
中科院分区：
文献类型：
--
作者：
Suzuki, Yayoi;Niwa, Mayu;Shiraishi, Hiroaki
本研究的目的是调查149名日本孕妇出生前邻苯二甲酸酯和多环芳烃暴露水平与分娩结局的关系。尿中9种邻苯二甲酸酯代谢物：邻苯二甲酸单甲酯(MMPs)、邻苯二甲酸单乙酯(MEP)、邻苯二甲酸单丁酯(MnBP)、邻苯二甲酸单苄酯(MBzP)、邻苯二甲酸单异辛酯(MEHP)、邻苯二甲酸单乙酯(MEHHP)、邻苯二甲酸单乙酯(MEOHP)、邻苯二甲酸单乙酯(MEOHP)、对孕妇现场尿样中邻苯二甲酸单异壬酯(MINP)、邻苯二甲酸单辛酯(MnOP)及多环芳烃(PAHs)代谢物1-羟基芘(1-OHP)进行了分析。对母体尿代谢物浓度与出生体重、身长、头围、胎龄等出生结局进行相关分析和多元回归分析。肌酐校正浓度(几何平均值；mUg/gcre)分别为9.14、9.76、51.6、5.62、5.45、10.6、11.3。0.031(MINP)、0.025(MnOP)和0.121(1-OHP)。这些浓度与文献值相当。产前接触邻苯二甲酸酯与出生结局之间的关系并不显著。1-OHP与出生体重、出生长度和头部环境呈显著负相关，但在多元回归分析中仅包括非吸烟者时相关性不显著。总而言之，我们发现，在目前受试者的暴露水平上，产前暴露于邻苯二甲酸酯或多环芳烃并不影响出生结局。(C)2010爱思唯尔有限公司。保留所有权利。
The purpose of this study was to investigate the relationship between the levels of prenatal exposure to phthalate ester and PAHs and birth outcomes among 149 Japanese pregnant women.Urinary concentrations of 9 phthalate ester metabolites, mono methyl phthalate (MMP), mono ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), mono benzyl phthalate (MBzP), mono-2-ethylhexyl phthalate (MEHP), mono-2-ethyl-5-hydroxyhexyl phthalate (MEHHP), mono-2-ethyl-5-oxohexyl phthalate (MEOHP), mono-iso-nonyl phthalate (MINP) and mono-n-octyl phthalate (MnOP) and PAHs metabolite (1-hydroxypyrene, 1-OHP) were analyzed in spot urine samples collected from pregnant women. Correlation analysis and multiple regression analysis were conducted between the concentrations of maternal urinary metabolites and birth outcomes such as birth weight, birth length, head circumference and gestational age. Creatinine-corrected concentration (geometric mean; mu g/g cre) was 9.14 (MMP), 9.76 (MEP), 51.6 (MnBP), 5.62 (MBzP), 5.45 (MEHP), 10.6 (MEHHP), 11.3 (MEOHP). 0.031 (MINP), 0.025 (MnOP) and 0.121 (1-OHP). These concentrations are comparable with literature value. The relationships between prenatal exposure to phthalate esters and birth outcomes were not significant. Statistically significant negative correlation was observed between 1-OHP and birth weight, birth length and head circumstances although the correlation was insignificant when only non-smokers were included in multiple regression analysis. In conclusion, we found that prenatal exposure to phthalate esters or PAHs did not affect birth outcomes at the exposure level of the present subjects. (C) 2010 Elsevier Ltd. All rights reserved.