Subcutaneously administered prolactin and 20K hGH, but not rGH or 22K hGH, prevent restraint stress-induced gastric ulcers in rats.
Subcutaneously administered prolactin and 20K hGH, but not rGH or 22K hGH, prevent restraint stress-induced gastric ulcers in rats.
复制标题
皮下注射催乳素和 20K hGH，而非 rGH 或 22K hGH，可以预防大鼠束缚应激诱发的胃溃疡。
作者：
K. Fujikawa;H. Fukuoka;K. Alam;H. Yoshizato;S. Higashimoto;H. Soya;M. Tanaka;K. Nakashima
压力会导致脊椎动物的胃溃疡。在人类，生长激素(HGH)和催乳素(HRPL)在应激条件下迅速释放到循环中，而在应激状态下，大鼠循环中的生长激素(RGH)水平下降，循环中的催乳素(RPRL)水平迅速上升。然而，循环中的rGH和rPRL在应激过程中的作用仍不清楚。在此，我们分析了与rPRL相比，22K hGH、20K hGH或RGH是否能影响水中束缚应激(RSW)诱导的胃溃疡。大鼠皮下注射(S.C.)前处理RPRL或20KhGH可明显预防7h RSW大鼠胃损伤的发生。南卡罗来纳州22K hGH对RSW暴露大鼠的细胞保护作用不明显，而S.C.RGH预处理对RSW所致胃损伤无明显保护作用。结果提示，rPRL和20K hGH作用于PRL受体，而不作用于GH受体，从而预防RSW所致的胃损伤。
Stress causes gastric ulcer in vertebrates. In humans, growth hormone (hGH) and prolactin (hRPL) are promptly released into the circulation under the stress conditions, while in rats exposed to stress, the circulating levels of GH (rGH) are decreased and the circulating PRL (rPRL) levels are rapidly increased as in humans during stress. However, the roles of the circulating rGH and rPRL during stress are still unclear. Here we analyzed whether 22K hGH, 20K hGH or rGH, when compared to rPRL, can affect restraint stress in water (RSW)-induced gastric ulcers. Pretreatments of rats with subcutaneously (s.c.) administered rPRL or 20K hGH clearly prevented the development of the gastric injuries in rats subjected to 7 h RSW. The s.c. pretreatment with 22K hGH resulted in little cytoprotection in the rats exposed to RSW, while s.c. pretreatment with rGH showed no such protective effect against RSW-induced gastric injuries. Results suggested that rPRL and 20K hGH were acting on PRL receptor, but not on GH receptor, to prevent RSW-induced gastric injuries.
给予半胱胺可耗尽大鼠组织中的生长抑素。
影响因子：
4.8
作者：
Szabo,S;Reichlin,S
通讯作者：
Reichlin,S