Comparison of Fasting Human Pancreatic Polypeptide Levels Among Patients With Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Type 2 Diabetes Mellitus.
Comparison of Fasting Human Pancreatic Polypeptide Levels Among Patients With Pancreatic Ductal Adenocarcinoma, Chronic Pancreatitis, and Type 2 Diabetes Mellitus.
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胰管腺癌、慢性胰腺炎和2型糖尿病患者空腹人胰多肽水平的比较。
DOI：
10.1097/mpa.0000000000001077
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发表时间：
2018
期刊：
影响因子：
2.9
通讯作者：
Chari,SureshT
中科院分区：
文献类型：
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作者：
Nagpal,SajanJivSingh;Bamlet,WilliamR;Kudva,YogishC;Chari,SureshT
目的人胰多肽（humanpancreaticpolypeptide，HPP）是腹胰分泌的一种激素。虽然餐后HPP水平已经在慢性胰腺炎（CP）和胰腺导管腺癌（PDAC）中进行了研究，但是在这些疾病中关于空腹HPP的数据有限。CP伴糖尿病（DM）（n= 16）、CP不伴DM（n= 34）、PDAC伴新发DM（n= 50）、PDAC不伴DM（n= 49）、新发2型DM（n= 50）、正常对照组（n= 49）。六十六有3C型糖尿病（CP与DM，n= 16; PDAC与新发DM，n= 50）。新发2型DM患者的中位（四分位距）HPP水平（n= 50; 288.3 [80.1-1072.1]）与3c型DM患者相似（n= 66; 242.3 [64.9-890.9]）（P= 0.71）。在PDAC（n= 99）中，无论是否患有DM，胰头（n= 75）与体/尾（n= 24）肿瘤的HPP值相似（245.3 [64.3-1091.3] vs 334.7 [136.1-841.5]; P= 0.95）。
ObjectivesHuman pancreatic polypeptide (HPP) is a hormone secreted by the ventral pancreas. While postprandial HPP levels have been studied in chronic pancreatitis (CP) and pancreatic ductal adenocarcinoma (PDAC), there are limited data on fasting HPP in these diseases.MethodsFasting serum HPP was measured in the following groups of patients: CP with diabetes mellitus (DM)(n= 16), CP without DM (n= 34), PDAC with new-onset DM (n= 50), PDAC without DM (n= 49), new-onset type 2 DM (n= 50), and controls without DM (n= 49). Sixty-six had type 3c DM (CP with DM, n= 16; PDAC with new-onset DM, n= 50).ResultsMedian fasting HPP levels (in picograms per milliliter) were similar among all groups. Median (interquartile range) HPP levels in new-onset type 2 DM (n= 50; 288.3 [80.1–1072.1]) were similar to those in type 3c DM (n= 66; 242.3 [64.9–890.9])(P= 0.71). In PDAC (n= 99), HPP values were similar in pancreatic head (n= 75) versus body/tail (n= 24) tumors (245.3 [64.3–1091.3] vs 334.7 [136.1–841.5]; P= 0.95), regardless of DM.Conclusions