Evidence for a spinal central pattern generator in humans
Evidence for a spinal central pattern generator in humans
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DOI：
10.1111/j.1749-6632.1998.tb09062.x
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发表时间：
1998-01-01
期刊：
影响因子：
--
通讯作者：
Pinter, MM
中科院分区：
文献类型：
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作者：
Dimitrijevic, MR;Gerasimenko, Y;Pinter, MM
在完全、长期的脊髓损伤患者中，对腰椎脊髓后部结构的非模式电刺激可以诱导模式的、运动样活动。我们证明，硬膜外脊髓刺激可以在截瘫患者中诱导阶梯式EMG活动和运动协同效应。在第二腰椎节段施加频率为25~60 Hz、幅度为5~9V的电刺激序列，可有效地诱发肢体的节律性、站姿交替和摆动相。这一发现表明，即使在脱离大脑控制的情况下，人类的脊髓回路也能够产生类似运动的活动，而且对脊髓的外部控制持续电刺激可以取代大脑产生的紧张性驱动。
Non-patterned electrical stimulation of the posterior structures of the lumbar spinal cord in subjects with complete, long-standing spinal cord Injury, can induce patterned, locomotor-like activity, We show that epidural spinal cord stimulation can elicit step-like EMG activity and locomotor synergies in paraplegic subjects. An electrical train of stimuli applied over the second lumbar segment with a frequency of 25 to 60 Hz and an amplitude of 5-9 V was effective in inducing rhythmic, alternating stance and swing phases of the lower limbs. This finding suggests that spinal circuitry in humans has the capability of generating locomotor-like activity even when isolated from brain control, and that externally controlled sustained electrical stimulation of the spinal cord can replace the tonic drive generated by the brain.