Comparison of combined urea and creatinine clearance and prediction equations as measures of residual renal function when GFR is low
Comparison of combined urea and creatinine clearance and prediction equations as measures of residual renal function when GFR is low
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DOI：
10.1093/qjmed/hcn032
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发表时间：
2008-08-01
影响因子：
13.3
通讯作者：
Isles, C.
中科院分区：
文献类型：
--
作者：
Almond, A.;Siddiqui, S.;Isles, C.
背景：英国、美国和欧洲的指南建议开始透析的决定应该基于肾功能、营养状况和临床症状的综合测量。这些建议假设肾小球滤过率（GFR）的测量是准确和可重复的。方法：对97例慢性肾脏疾病（CKD）患者进行前瞻性研究，患者血清肌酐bb0 200 mol/l (2.26 mg/dl)， 24 h尿液收集388例。我们的主要结局指标是使用广泛接受的阈值，通过不同的测试确定的低残余肾功能患者的数量。我们使用尿素和肌酐清除率的组合来计算每个比较的敏感性、特异性、阳性和阴性预测值和受试者工作特征曲线
Background: UK, US and European guidelines recommend the decision to initiate dialysis should be based on a combination of measurements of kidney function, nutritional status and clinical symptoms. Such recommendations assume an accurate and reproducible measure of glomerular filtration rate (GFR).Methods: Prospective study of 97 patients with chronic kidney disease (CKD) and serum creatinine >200 mol/l (2.26 mg/dl) who between them contributed 388 24 h urine collections. Our main outcome measure was the number of patients with low residual renal function identified by different tests, using widely accepted thresholds. We calculated sensitivity, specificity, positive and negative predictive values and receiver operating characteristic curves for each comparison using a combined urea and creatinine clearance of