Cutaneous permeability barrier repair following various types of insults: kinetics and effects of occlusion.
Cutaneous permeability barrier repair following various types of insults: kinetics and effects of occlusion.
复制标题
各种类型损伤后的皮肤渗透性屏障修复：动力学和闭塞效应。
DOI：
10.1159/000211406
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Feingold,KR
中科院分区：
文献类型：
--
作者：
Taljebini,M;Warren,R;Mao-Oiang,M;Lane,E;Elias,PM;Feingold,KR
先前的研究表明，丙酮对皮肤渗透屏障的急性破坏会导致最初的快速修复阶段，随后是较慢的修复阶段。在本研究中，我们证明通过其他机制破坏屏障的操作（例如胶带剥离或清洁剂处理）具有类似的屏障修复模式。在所有三个模型中，脂质返回角质层与屏障功能正常化平行，并且在破坏屏障后立即阻塞会阻止脂质返回和功能正常化。此外，屏障破坏后 6-8 小时开始的闭塞阻止了后期、较慢的修复阶段，表明后期阶段可以独立于初始阶段而受到抑制。最后，屏障的严重和相对较小的扰动都会引起具有相似动力学模式的修复反应。总之，本研究表明，无论屏障破坏的病因或程度如何，屏障修复反应都是相似的。
Previous studies have shown that acute disruption of the cutaneous permeability barrier by acetone results in an initial rapid phase of repair followed by a later, slower phase. In the present study, we demonstrate that manipulations which disrupt the barrier by other mechanisms, such as tape stripping or detergent treatment, have a similar pattern of barrier repair. In all three models, the return of lipid to the stratum corneum parallels the normalization of barrier function, and occlusion immediately after disrupting the barrier blocks both the return of lipid and the normalization of function. Moreover, occlusion beginning 6-8 h following barrier disruption blocks the late, slower phase of repair, indicating that the late phase can be inhibited independently of the initial phase. Lastly, both severe and relatively minor perturbations of the barrier elicit a repair response with a similar kinetic pattern. In summary, the present study demonstrates that barrier repair responses are similar regardless of the etiology or extent of barrier disruption.