The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs
The concentration of sympathin in different parts of the central nervous system under normal conditions and after the administration of drugs
复制标题
正常情况下及给药后中枢神经系统不同部位交感神经的浓度
DOI：
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发表时间：
1954
期刊：
影响因子：
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通讯作者：
M. Vogt
中科院分区：
文献类型：
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作者：
M. Vogt
von Euler（1946）和Holtz（1950）已经证实了去甲肾上腺素和肾上腺素在大脑中的存在。毫无疑问，这些物质被认为发生在脑血管舒缩神经中。目前的研究关注的问题是，这些拟交感神经胺除了作为血管舒缩末梢的递质外，是否在中枢神经组织本身的功能中起作用。在本文中，这些胺将被称为“交感神经”，因为它们被发现总是一起出现，去甲肾上腺素代表主要成分，这是周围交感神经系统的递质特征。解决大脑交感神经功能问题的第一个方法是确定它在大脑和脊髓不同部位的分布。这种方法在研究胆碱乙酰化酶（Feldberg & Vogt, 1948）酶系统的功能作用方面被证明是卓有成效的，因为人们发现胆碱乙酰化酶的浓度在不同地区差异很大。这表明只有某些神经元使用乙酰胆碱作为它们的传递物质。正如其他地方的简要报道（Vogt, 1952a），人们发现同情也具有特定的分布模式。这一事实表明，尽管不能证明，这些胺在大脑中浓度高的区域的特殊功能中起着一定的作用。在狗的同情分布模式的详细地图准备：它形成了本文的第一部分。第二部分涉及药物引起的脑交感物质浓度的变化，以及从这些观察中可能得出的推论。由于已知中枢神经系统的交感神经的总量非常小（在20 - 200ng /g*之间）
The presence of noradrenaline and adrenaline in the brain has been demonstrated by von Euler (1946) and Holtz (1950). These substances were supposed, undoubtedly correctly, to occur in the cerebral vasomotor nerves. The present work is concerned with the question whether these sympathomimetic amines, besides their role as transmitters at vasomotor endings, play a part in the function of the central nervous tissue itself. In this paper, these amines will be referred to as 'sympathin', since they were found invariably to occur together, with noradrenaline representing the major component, as is characteristic for the transmitter of the peripheral sympathetic system. A first approach to the problem of the function of cerebral sympathin was the determination of its distribution in different parts of the brain and spinal cord. Such an approach had proved fruitful in the investigation of the functional role of the enzyme system cholinacetylase (Feldberg & Vogt, 1948), the concentration of which was found to vary greatly in different regions. This had suggested that only certain neurones made use of acetylcholine as their transmitter substance. As briefly reported elsewhere (Vogt, 1952a), sympathin, too, was found to possess a specific pattern of distribution. This very fact suggests, though it does not prove, that these amines play a part in the specialized function of those regions of the brain in which their concentration is high. A detailed map of the pattern of distribution of sympathin was prepared in the dog: it forms the first part of this paper. The second part deals with changes in the concentration of brain sympathin produced by drugs and the inferences which may be drawn from such observations. Since it was known that the total amounts of sympathin in the central nervous system were very small (between 20 and 200 ng/g* according to