PIRD: Pan Immune Repertoire Database
PIRD: Pan Immune Repertoire Database
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DOI：
10.1093/bioinformatics/btz614
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发表时间：
2020-02-01
期刊：
影响因子：
5.8
通讯作者：
Liu, Xiao
中科院分区：
文献类型：
--
作者：
Zhang, Wei;Wang, Longlong;Liu, Xiao
动机：T和B细胞受体(TCR和BCR)通过识别大量不同的外部和内部抗原，在适应性免疫系统中发挥关键作用。了解这些受体对于探索免疫反应的过程以及在免疫治疗和抗体药物设计中开发潜在的应用至关重要。尽管近年来大量的样品已经使用高通量测序对其TCR和BCR谱系进行了测序，但很少有数据库被构建来存储这些类型的数据。为了解决这个问题，我们开发了一个数据库。结果：我们开发了一个数据库，位于中国国家基因库(CNGBdb)，用于收集和存储包括智人和其他物种的注释TCR和BCR序列数据。除了数据存储，PIRD还提供数据可视化和交互式在线分析功能。此外，针对已知抗原的TCR和BCRs数据库(TbAdb)也存放在PIRD中。
Motivation: T and B cell receptors (TCRs and BCRs) play a pivotal role in the adaptive immune system by recognizing an enormous variety of external and internal antigens. Understanding these receptors is critical for exploring the process of immunoreaction and exploiting potential applications in immunotherapy and antibody drug design. Although a large number of samples have had their TCR and BCR repertoires sequenced using high-throughput sequencing in recent years, very few databases have been constructed to store these kinds of data. To resolve this issue, we developed a database.Results: We developed a database, the Pan Immune Repertoire Database (PIRD), located in China National GeneBank (CNGBdb), to collect and store annotated TCR and BCR sequencing data, including from Homo sapiens and other species. In addition to data storage, PIRD also provides functions of data visualization and interactive online analysis. Additionally, a manually curated database of TCRs and BCRs targeting known antigens (TBAdb) was also deposited in PIRD.