How Human Is Human Connectional Neuroanatomy?
How Human Is Human Connectional Neuroanatomy?
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DOI：
10.3389/fnana.2020.00018
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发表时间：
2020-04
影响因子：
2.9
通讯作者：
R. Rushmore;S. Bouix;M. Kubicki;Y. Rathi;E. Yeterian;N. Makris
中科院分区：
文献类型：
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作者：
R. Rushmore;S. Bouix;M. Kubicki;Y. Rathi;E. Yeterian;N. Makris
人类大脑的结构已被广泛研究。尽管积累了所有的知识，但关于人类大脑中从起源到终止的连接的直接信息非常有限。然而，有一种普遍的误解，认为人类的连接神经解剖学已经得到了很好的建立和验证。在这篇文章中，我们认为什么是已知的直接对人类的结构和连接神经解剖学。人类大脑中神经解剖学连接的信息主要来自非人类实验模型的研究，其中整个连接途径，包括起源，过程和终止，都是直接可视化的。研究人类大脑结构连接的技术正在迅速发展;然而，我们目前对这种连接的理解主要限于来自同源比较的数据，特别是与非人类灵长类动物的同源比较。我们采取的立场，深入和更精确的了解人类连接神经解剖学将获得系统的应用，这种同源的方法。
The structure of the human brain has been studied extensively. Despite all the knowledge accrued, direct information about connections, from origin to termination, in the human brain is extremely limited. Yet there is a widespread misperception that human connectional neuroanatomy is well-established and validated. In this article, we consider what is known directly about human structural and connectional neuroanatomy. Information on neuroanatomical connections in the human brain is derived largely from studies in non-human experimental models in which the entire connectional pathway, including origins, course, and terminations, is directly visualized. Techniques to examine structural connectivity in the human brain are progressing rapidly; nevertheless, our present understanding of such connectivity is limited largely to data derived from homological comparisons, particularly with non-human primates. We take the position that an in-depth and more precise understanding of human connectional neuroanatomy will be obtained by a systematic application of this homological approach.