Principles of unconventional myosin function and targeting.
Principles of unconventional myosin function and targeting.
复制标题
DOI：
10.1146/annurev-cellbio-100809-151502
复制
发表时间：
2011
影响因子：
11.3
通讯作者：
Spudich JA
中科院分区：
文献类型：
--
作者：
Hartman MA;Finan D;Sivaramakrishnan S;Spudich JA
非常规肌球蛋白是一个以肌动蛋白为基础的马达超家族，参与多种细胞过程。近年来，对它们的生物物理性质的描述取得了很大进展，对它们的细胞功能的分析也取得了进展。在这里，我们专注于指导体内运动功能和靶向特定细胞位置的原则。我们没有全面描述每个电机，而是概述了整个超家族研究中出现的主要主题，并使用具体示例来说明每个主题。在以这种格式呈现数据时，我们试图确定每个领域的开放问题，并指出它们之间的共同点。为了进一步了解肌球蛋白在体内的作用，显然我们必须确定它们的细胞货物和调节运动附着的蛋白质复合物，以充分了解它们在细胞和发育水平上的功能。
Unconventional myosins are a superfamily of actin-based motors implicated in diverse cellular processes. In recent years, much progress has been made in describing their biophysical properties, and headway has been made into analyzing their cellular functions. Here, we focus on the principles that guide in vivo motor function and targeting to specific cellular locations. Rather than describe each motor comprehensively, we outline the major themes that emerge from research across the superfamily and use specific examples to illustrate each. In presenting the data in this format, we seek to identify open questions in each field as well as to point out commonalities between them. To advance our understanding of myosins’ roles in vivo, clearly we must identify their cellular cargoes and the protein complexes that regulate motor attachment to fully appreciate their functions on the cellular and developmental levels.