Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?
Do interactions between SNCA, MAPT, and LRRK2 genes contribute to Parkinson's disease susceptibility?
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DOI：
10.1016/j.parkreldis.2011.07.001
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发表时间：
2011-12-01
影响因子：
4.1
通讯作者：
Maraganore, Demetrius M.
中科院分区：
文献类型：
--
作者：
Biernacka, Joanna M.;Armasu, Sebastian M.;Maraganore, Demetrius M.
背景：SNCA、MAPT和LRRK2基因多态性最近被证实是帕金森病（PD）的危险因素，尽管个体归因风险较小。在这里，我们研究了PD与这些基因变体之间相互作用的关系。方法：作为PD易感基因119 SNCA、MAPT和LRRK2单倍型标记单核苷酸多态性（SNPs）和两个可变数串联重复序列（VNTRs）的先前研究的一部分，对来自美国中西部北部的1098例PD患者和1098名匹配的对照进行了基因分型。选取其中26个snp进行SNP-SNP（或SNP-VNTR或VNTR-VNTR）互作分析（256对互作）。采用病例对照分析研究SNP的成对相互作用与PD易感性的关系。结果：在所调查的256个相互作用对中，有10个具有未校正的p值
Background: Polymorphisms in SNCA, MAPT and LRRK2 genes have recently been confirmed as risk factors for Parkinson's disease (PD), although with small individual attributable risk. Here we investigated the association of PD with interactions between variants of these genes.Methods: As part of a previous study of PD susceptibility genes 119 SNCA, MAPT, and LRRK2 haplotype tagging single nucleotide polymorphisms (SNPs) and two variable number tandem repeats (VNTRs) were genotyped in 1098 PD cases from the upper Midwest, USA and 1098 matched controls. Twenty-six of these SNPs were selected for SNP-SNP (or SNP-VNTR or VNTR-VNTR) interaction analysis (256 interaction pairs). Case-control analyses were performed to study association of pairwise SNP interactions with PD susceptibility.Results: Out of the 256 interaction pairs investigated, 10 had uncorrected p-values