Environmental control of microtubule-based bidirectional cargo transport
Environmental control of microtubule-based bidirectional cargo transport
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DOI：
10.1209/0295-5075/107/18004
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发表时间：
2014-07-01
期刊：
影响因子：
1.8
通讯作者：
Santen, Ludger
中科院分区：
文献类型：
--
作者：
Klein, Sarah;Appert-Rolland, Cecile;Santen, Ludger
在细胞内部，各种各样的货物由分子马达团队运输。有趣的是，所涉及的电机通常具有相反的拉动方向，因此所产生的货物动力学是有偏的随机运动。细胞如何控制这种偏见是一个悬而未决的问题。在这里，我们建立了一个模型，明确地考虑了货物与每个电机的弹性耦合。我们表明，偏差可以通过改变施加在货物上的外力或改变环境特性，以一种违反直觉的方式简单地控制甚至逆转。此外，在短时间尺度上发现的超扩散行为表明，由货物介导的耦合引起的运动合作的出现。中国人民解放军版权所有
Inside cells, various cargos are transported by teams of molecular motors. Intriguingly, the motors involved generally have opposite pulling directions, and the resulting cargo dynamics is a biased stochastic motion. It is an open question how the cell can control this bias. Here we develop a model which takes explicitly into account the elastic coupling of the cargo with each motor. We show that bias can be simply controlled or even reversed in a counterintuitive manner via a change in the external force exerted on the cargo or a variation of the environmental properties. Furthermore, the superdiffusive behavior found at short time scales indicates the emergence of motor cooperation induced by cargo-mediated coupling. Copyright (C) EPLA, 2014