Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi
Antitumor and immunomodulatory activities of a polysaccharide from Artemisia argyi
复制标题
DOI：
10.1016/j.carbpol.2013.07.018
复制
发表时间：
2013-10-15
影响因子：
11.2
通讯作者：
Lan, Minbo
中科院分区：
文献类型：
--
作者：
Bao, Xiaoli;Yuan, Huihui;Lan, Minbo
从艾蒿（Artemisia argyi）中分离得到一种水溶性多糖（FAAP-02），由N-乙酰-D-氨基葡萄糖、葡萄糖、甘露糖、半乳糖、鼠李糖、阿拉伯糖、木糖和核糖组成，平均分子量为5169 Da。FAAP-02通过腹腔给药在荷肉瘤180（S180）的小鼠中评价抗肿瘤和免疫调节活性。结果表明，FAAP-02能显著抑制S180移植瘤的生长，延长荷瘤小鼠的生存时间。FAAP-02还能明显提高移植瘤和/或5-FU抑制的小鼠胸腺指数、脾脏指数、血清白细胞介素2（IL-2）、白细胞介素6（IL-6）、白细胞介素12（IL-12）和肿瘤坏死因子-α（TNF-α）水平及脾T淋巴细胞CD 4+、CD 8+表达。这些结果表明FAAP-02的抗肿瘤活性可能与其免疫刺激作用有关。(C)2013爱思唯尔有限公司版权所有。
A water-soluble polysaccharide (FAAP-02), composed of N-acetyl-D-glucosamine, glucose, mannose, galactose, rhamnose, arabinose, xylose and ribose, with an average molecular weight of 5169 Da, was isolated from Artemisia argyi. The antitumor and immunomodulatory activities of FAAP-02 were evaluated in Sarcoma 180 (S180) tumor-bearing mice by intraperitoneal administration. As a result, FAAP-02 significantly inhibited the growth of the S180 transplanted tumors and prolonged the survival time of the tumor-bearing mice. Moreover, FAAP-02 could obviously increase the thymus and spleen indices, the levels of serum Interleukin 2 (IL-2), Interleukin 6 (IL-6), Interleukin 12 (IL-12) and tumor necrosis factor-alpha (TNF-alpha) and the expression of CD4+ and CD8+ splenic T lymphocytes which were suppressed by the transplanted tumor or/and 5-fluorouracil (5-FU) in the mice. These results indicated that the antitumor activity of FAAP-02 might be associated with its immunostimulatory effects. (C) 2013 Elsevier Ltd. All rights reserved.