Direct flow separation strategy, to isolate no-carrier-added 90Nb from irradiated Mo or Zr targets
Direct flow separation strategy, to isolate no-carrier-added 90Nb from irradiated Mo or Zr targets
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DOI：
10.1515/ract-2015-2543
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发表时间：
2016-09
影响因子：
1.8
通讯作者：
V. Radchenko;D. Filosofov;J. Dadakhanov;D. Karaivanov;A. Marinova;A. Baimukhanova;F. Roesch
中科院分区：
文献类型：
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作者：
V. Radchenko;D. Filosofov;J. Dadakhanov;D. Karaivanov;A. Marinova;A. Baimukhanova;F. Roesch
90Nb的中间半衰期为14.6 h，正电子分支率高达53%，每次衰变β+的最佳发射能量仅为0.35 MeV。这些有利的特性表明它可能是一种潜在的候选应用于免疫pet。我们最近的目标是研究阴离子交换树脂（AG 1 × 8）和UTEVA树脂在HCl/H2O2和HCl/草酸混合物中ZrIV和NbV的分布系数，以开发90Nb的“直接流动”分离策略。直接流动的概念是指使用单个洗脱液在多个色谱柱上完成分离，有效地简化了分离过程并提高了时间效率。最后，我们还证明了这种分离策略适用于通过照射钼靶产生正电子发射器90Nb并从照射的钼靶中分离出90Nb。
Abstract 90Nb has an intermediate half-life of 14.6 h, a high positron branching of 53% and optimal β+ emission energy of only Emean 0.35 MeV per decay. These favorable characteristics suggest it may be a potential candidate for application in immuno-PET. Our recent aim was to conduct studies on distribution coefficients for ZrIV and NbV in mixtures of HCl/H2O2 and HCl/oxalic acid for anion exchange resin (AG 1 × 8) and UTEVA resin to develop a “direct flow” separation strategy for 90Nb. The direct flow concept refers to a separation accomplished using a single eluent on multiple columns, effectively streamlining the separation process and increasing the time efficiency. Finally, we also demonstrated that this separation strategy is applicable to the production of the positron emitter 90Nb via the irradiation of molybdenum targets and isolation of 90Nb from the irradiated molybdenum target.