Simultaneous multiparameter whole blood hemostasis assessment using a carbon nanotube-paper composite capacitance sensor
Simultaneous multiparameter whole blood hemostasis assessment using a carbon nanotube-paper composite capacitance sensor
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DOI：
10.1016/j.bios.2021.113786
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发表时间：
2021-11-18
影响因子：
12.6
通讯作者：
Gao, Dayong
中科院分区：
文献类型：
--
作者：
Sekar, Praveen K.;Liang, Xin M.;Gao, Dayong
快速和准确的止血临床评估是必不可少的管理患者谁接受侵入性手术，经历出血，或接受抗血栓治疗。止血包括细胞和非细胞血液成分之间的相互作用，但目前的设备只能评估这一复杂过程的部分方面。在这项工作中，我们描述了一种使用碳纳米管-纸复合材料（CPC）电容传感器同时评估凝血功能、血小板计数或功能和红细胞压积的新方法的发展。CPC电容对1.3 MHz凝血的响应提供了对多种凝血元素具有不同灵敏度的三个传感参数。进行全血止血评估，以证明开发的传感器对各种止血条件的潜在效用，包括病理条件，如血友病和血小板减少症。结果显示良好的协议时，与传统的血栓弹性成像。综上所述，CPC电容传感器是一种很有前途的新型生物医学设备，可以方便地进行非接触全血综合止血评估。
Rapid and accurate clinical assessment of hemostasis is essential for managing patients who undergo invasive procedures, experience hemorrhages, or receive antithrombotic therapies. Hemostasis encompasses an ensemble of interactions between the cellular and non-cellular blood components, but current devices assess only partial aspects of this complex process. In this work, we describe the development of a new approach to simultaneously evaluate coagulation function, platelet count or function, and hematocrit using a carbon nanotube-paper composite (CPC) capacitance sensor. CPC capacitance response to blood clotting at 1.3 MHz provided three sensing parameters with distinctive sensitivities towards multiple clotting elements. Whole blood-based hemostasis assessments were conducted to demonstrate the potential utility of the developed sensor for various hemostatic conditions, including pathological conditions, such as hemophilia and thrombocytopenia. Results showed good agreements when compared to a conventional thromboelastography. Overall, the presented CPC capacitance sensor is a promising new biomedical device for convenient non-contact whole-blood based comprehensive hemostasis evaluation.