INTRAVENOUS TYRAMINE RESPONSE IN MIGRAINE BEFORE AND DURING TREATMENT WITH INDORAMIN
INTRAVENOUS TYRAMINE RESPONSE IN MIGRAINE BEFORE AND DURING TREATMENT WITH INDORAMIN
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DOI：
10.1136/bmj.1.6070.1191
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发表时间：
1977-01-01
影响因子：
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通讯作者：
CARROLL, D
中科院分区：
文献类型：
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作者：
GHOSE, K;COPPEN, A;CARROLL, D
我们研究了31名偏头痛患者（20名女性，11名男性）对静脉注射酪胺的反应（酪胺升压反应试验）。在一项双盲交叉试验中，患者接受了pacebo片剂或吲哚拉明和α-肾上腺素能阻滞剂的治疗。我们发现，与对照组相比，偏头痛患者需要显著减少酪胺，以增加他们的cyberblod压力30毫米汞柱。在偏头痛患者中，吲哚拉明显著增加了升高收缩压所需的酪胺量，并使酪胺后偏头痛的发生率降低了46%，而服用安慰剂的患者在服用吲哚拉明时降低了8%。酪胺敏感性与经前偏头痛或饮食偏头痛史之间没有关联，男性和女性之间酪胺后偏头痛的发病率也没有显著差异。我们的结论是，静脉酪胺试验可能是有价值的偏头痛患者评估谁将作出反应的α-肾上腺素能阻断剂，如吲哚拉明。
We studied the response of 31 migraine sufferers (20 women, 11 men) to intravenous tyramine (the tyraminedose)pressor response test). Patients were treated either with pacebo tablets or indoramin, and alpha-adrenergic blocking agent, in a double-blind crrossover trial. We found that patients with migraine required significantly less tyramine to increase their cystolic blod pressure by 30 mm Hg when compared with matched controls. Indoramin significantly increased the amount of tyramine needed to raise the systolic blood pressure among migraine suffers and reduced the incidence of posttyramine migraine for m 46% while patients were on placebo tablets to 8% when they were receiveing indoramin. There was no association between tyramine sensitivity and a history of premenstrual or dietary migraine, nor was there a significant difference in the indierenence in the incidence of post-tyramine migrain between men women. We conclude that the intravenous tyramine test may be valuable in assessing migraine suffers who will respond to an alpha-advenergic blocking agent such as indoramin.