The use of thermal treatments to enhance the mechanical properties of electrospun poly (ε-caprolactone) scaffolds
The use of thermal treatments to enhance the mechanical properties of electrospun poly (ε-caprolactone) scaffolds
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DOI：
10.1016/j.biomaterials.2007.11.024
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发表时间：
2008-04-01
期刊：
影响因子：
14
通讯作者：
Yoo, James J.
中科院分区：
文献类型：
--
作者：
Lee, Sang Jin;Oh, Se Heang;Yoo, James J.
利用静电纺丝技术制备的非织造生物支架已广泛应用于组织工程领域。虽然电纺生物支架满足组织工程应用的许多要求，但它们有时缺乏必要的生物力学性能。为了改善静电纺聚己内酯（PCL）支架的生物力学性能，采用热处理方法对纤维进行粘合。在Pluronic F127溶液中在54 ℃至60 ℃的温度范围内进行热纤维粘合。通过分析形态、纤维直径、孔面积、拉伸性能、缝合保持强度、爆破压力强度和顺应性的变化，表征热粘合电纺PCL支架。与未处理的PCL支架相比，热粘合静电纺丝PCL支架的生物力学性能显著增加，而没有任何肉眼可见的和超微结构的变化。这项研究表明，引入热纤维粘合到电纺PCL支架，改善了这些支架的生物力学性能，使它们更适合于组织工程应用。(c)2007爱思唯尔有限公司版权所有。
Nonwoven nanofiber scaffolds fabricated by electrospinning technology have been widely used for tissue engineering applications. Although electrospun nanofiber scaffolds fulfill many requirements for tissue engineering applications, they sometimes lack the necessary biomechanical properties. TO attempt to improve the biomechanical properties of electrospun poly(E-caprolactone) (PCL) scaffolds, fibers were bonded by thermal treatment. The thermal fiber bonding was performed in Pluronic F127 solution at a range of temperatures from 54 degrees C to 60 degrees C. Thermally bonded electrospun PCL scaffolds were characterized by analyzing the changes in morphology, fiber diameter, pore area, tensile properties, suture retention strength, burst pressure strength, and compliance. The biomechanical properties of the thermally bonded electrospun PCL scaffolds were significantly increased without any gross observable and ultrastructural changes when compared to untreated PCL scaffolds. This study suggests that the introduction of thermal fiber bonding to electrospun PCL scaffolds improved the biomechanical properties of these scaffolds, making them more suitable for tissue engineering applications. (c) 2007 Elsevier Ltd. All rights reserved.