Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d'Ivoire.
Divergent lineage of a novel hantavirus in the banana pipistrelle (Neoromicia nanus) in Côte d'Ivoire.
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DOI：
10.1186/1743-422x-9-34
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发表时间：
2012-01-26
期刊：
影响因子：
4.8
通讯作者：
Yanagihara R
中科院分区：
文献类型：
--
作者：
Sumibcay L;Kadjo B;Gu SH;Kang HJ;Lim BK;Cook JA;Song JW;Yanagihara R
最近发现的汉坦病毒窝藏的鼩 鼱和鼹鼠（目的Soricomorpha）表明，其他哺乳动物有共同的祖先可能作为水库。为了研究这种可能性，档案组织从213食虫蝙蝠（翼手目）进行了分析汉坦病毒RNA的RT-PCR。在多次尝试失败后，2011年6月在西非科特迪瓦Mouyassué村附近捕获的两只香蕉伏翼（Neoromicia nanus）的乙醇固定肝组织中检测到汉坦病毒RNA。使用最大似然法和贝叶斯法对部分L-片段序列进行系统发育分析，发现新发现的汉坦病毒，命名为穆亚苏埃病毒（MOUV），与所有其他啮齿动物和虫形虫传播的汉坦病毒高度分化和基础，除了欧洲普通鼹鼠（Talpa europaea）中的Nova病毒。MOUV的全基因组测序和对其他蝙蝠物种汉坦病毒的进一步调查目前正在进行中，这将为汉坦病毒的进化和多样化提供重要的见解。
Recently identified hantaviruses harbored by shrews and moles (order Soricomorpha) suggest that other mammals having shared ancestry may serve as reservoirs. To investigate this possibility, archival tissues from 213 insectivorous bats (order Chiroptera) were analyzed for hantavirus RNA by RT-PCR. Following numerous failed attempts, hantavirus RNA was detected in ethanol-fixed liver tissue from two banana pipistrelles (Neoromicia nanus), captured near Mouyassué village in Côte d'Ivoire, West Africa, in June 2011. Phylogenetic analysis of partial L-segment sequences using maximum-likelihood and Bayesian methods revealed that the newfound hantavirus, designated Mouyassué virus (MOUV), was highly divergent and basal to all other rodent- and soricomorph-borne hantaviruses, except for Nova virus in the European common mole (Talpa europaea). Full genome sequencing of MOUV and further surveys of other bat species for hantaviruses, now underway, will provide critical insights into the evolution and diversification of hantaviruses.