Uncovering the Mechanisms of Shrimp Innate Immune Response by RNA Interference
Uncovering the Mechanisms of Shrimp Innate Immune Response by RNA Interference
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DOI：
10.1007/s10126-010-9292-0
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发表时间：
2011-08
影响因子：
3
通讯作者：
I. Hirono;F. Fagutao;H. Kondo;T. Aoki
中科院分区：
文献类型：
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作者：
I. Hirono;F. Fagutao;H. Kondo;T. Aoki
由于对虾在世界水产养殖中的重要性，人们对了解其免疫系统以提高其对病原微生物的抵抗力非常感兴趣。RNA干扰（RNAi）是研究对虾免疫应答相关基因的有效工具。RNAi最初被认为是针对RNA病毒的抗病毒反应，是由双链RNA触发并导致同源基因降解的细胞机制。本文综述了近年来利用RNAi技术对对虾基因进行功能研究的进展。我们还回顾了RNAi在虾中引起抗病毒反应的潜力。
Because of the importance of shrimp in world aquaculture, there is much interest in understanding their immune system in order to improve their resistance to pathogenic microorganisms. An effective tool in studying genes involved in the immune response in shrimp is RNA interference (RNAi). RNAi, first recognized as an antiviral response against RNA viruses, is a cellular mechanism that is triggered by double-stranded RNAs and results in the degradation of homologous genes. In this review, we describe the current studies of genes in shrimp that employed RNAi technology to elucidate or confirm their functions. We also review the potential of RNAi to elicit antiviral response in shrimp.