Structure and function of histone acetyltransferase MOF.
Structure and function of histone acetyltransferase MOF.
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DOI：
10.3934/biophy.2015.4.555
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发表时间：
2015
期刊：
影响因子：
1.5
通讯作者：
Sun H
中科院分区：
文献类型：
--
作者：
Chen QY;Costa M;Sun H
MOF首先在果蝇中被鉴定为剂量补偿复合物的重要组分。作为组蛋白乙酰转移酶MYST家族的成员，MOF特异性地将乙酰基沉积到组蛋白H4赖氨酸16上。在整个进化过程中，MOF及其哺乳动物直系同源物保留了高度保守的底物特异性和相似的酶活性。MOF在剂量补偿、ESC自我更新、DNA损伤和修复、细胞存活和基因表达调控中起重要作用。MOF的调节异常与许多类型的人类癌症的肿瘤形成和进展有关。本文就哺乳动物hMOF的结构、活性及其在H4K16乙酰化、DNA损伤反应、干细胞多能性和肿瘤发生中的作用作一综述。
MOF was first identified in Drosophila melanogaster as an important component of the dosage compensation complex. As a member of MYST family of histone acetyltransferase, MOF specifically deposits the acetyl groups to histone H4 lysine 16. Throughout evolution, MOF and its mammalian ortholog have retained highly conserved substrate specificity and similar enzymatic activities. MOF plays important roles in dosage compensation, ESC self-renewal, DNA damage and repair, cell survival, and gene expression regulation. Dysregulation of MOF has been implicated in tumor formation and progression of many types of human cancers. This review will discuss the structure and activity of mammalian hMOF as well as its function in H4K16 acetylation, DNA damage response, stem cell pluripotency, and carcinogenesis.