Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas
Up-regulated expression of Ezrin and c-Met proteins are related to the metastasis and prognosis of gastric carcinomas
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Ezrin、c-Met蛋白表达上调与胃癌转移及预后相关
DOI：
10.14670/hh-26.1111
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发表时间：
2011-09-01
影响因子：
2
通讯作者：
Xin, Yan
中科院分区：
文献类型：
--
作者：
Zhao, Jing;Zhang, Xiaoxiao;Xin, Yan
近年来研究表明Ezrin和c-Met蛋白的异常表达与多种肿瘤的发生、转移及预后有关。本研究检测Ezrin和c-Met蛋白在正常胃黏膜、慢性萎缩性胃炎、肠上皮化生、异型增生及胃癌组织中的表达，并分析其与胃癌转移及预后的关系。结果表明Ezrin和c-Met的过度表达与胃癌的发生、发展有关。我们的研究结果还表明，在胃癌中联合检测这两种肿瘤特异性生物标志物可以在预测患者预后方面提供额外的功效。
Recent publications demonstrated that abnormal expression of Ezrin and c-Met proteins were related to carcinogenesis, metastasis and prognosis of various sorts of tumors. In this study we detected the expressions of Ezrin and c-Met proteins in normal gastric mucosa, chronic atrophic gastritis, intestinal metaplasia, dysplasia and gastric carcinoma and analyzed the correlations with metastasis and prognosis of gastric carcinomas. The results demonstrated that both Ezrin and c-Met overexpression were related to the occurrence and progression of gastric carcinoma. Our findings also demonstrated that combined detection of these two tumor-specific biomarkers in gastric carcinomas can provide additional efficacy in predicting the patients' outcomes.