Enhanced blood plasma separation by modulation of inertial lift force
Enhanced blood plasma separation by modulation of inertial lift force
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DOI：
10.1016/j.snb.2013.08.092
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发表时间：
2014-01-01
影响因子：
8.4
通讯作者：
Park, Je-Kyun
中科院分区：
文献类型：
--
作者：
Lee, Myung Gwon;Shin, Joong Ho;Park, Je-Kyun
本文介绍了在收缩-膨胀阵列（CEA）微通道中通过调制用于分离的惯性升力来增强血浆分离。通过改变收缩通道长度，我们观察了基于尺寸的颗粒分离的力调制效应。在CEA装置中，有两个力分量作用于相反的方向，以按大小分离颗粒。通过延长CEA微通道中的收缩区域，我们可以轻松地通过调节单个力分量（惯性升力）来控制所需粒子的横向迁移，而不会影响另一个力分量（Dean阻力）。根据实验结果，计算惯性力比，预测惯性升力与迪安阻力之间的力优势，并将其应用于CEA血浆分离微装置的设计参数确定。利用微通道中的力调制，我们成功地展示了从人全血中增强惯性血浆分离的能力，具有很高的血细胞排斥率，分离率分别为92.6%和69.5%，吞吐量为5.4 x 10（11）个细胞/分钟。(C) 2013 Elsevier B.V.版权所有
This paper describes enhanced blood plasma separation by modulating the inertial lift force for separation in a contraction-expansion array (CEA) microchannel. By changing a contraction channel length, we observed the force modulation effects for size-based particle separation. In the CEA device, there are two force components that act in opposite direction to separate particles by size. By lengthening the contraction region in the CEA microchannel, we can easily control the lateral migration of desired particles by modulating a single force component (inertial lift force) without affecting the other (Dean drag force). From the experimental results, the inertial force ratio was calculated for prediction of force superiority between inertial lift force and Dean drag force, and applied to determine design parameters of the CEA microdevice for blood plasma separation. Using the force modulation in the microchannel, we successfully demonstrated enhancement of inertial blood plasma separation from human whole blood with a substantially high blood cell rejection ratio and a separation yield of 92.6% and 69.5%, respectively, with a throughput of 5.4 x 10(11) cells/min. (C) 2013 Elsevier B.V. All rights reserved.