Pain in central and peripheral demyelinating disorders - Multiple sclerosis and Guillain-Barre syndrome
Pain in central and peripheral demyelinating disorders - Multiple sclerosis and Guillain-Barre syndrome
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DOI：
10.1016/s0733-8619(05)70103-1
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发表时间：
1998-11-01
影响因子：
2.4
通讯作者：
Moulin, DE
中科院分区：
文献类型：
--
作者：
Moulin, DE
中度至重度疼痛是中枢和外周脱髓鞘疾病的共同特征。多发性硬化症的疼痛往往发生在疾病已经确立的时候，并且通常会无限地徘徊。格林-巴利综合征的疼痛在最初出现时往往特别严重，通常在8至12周内消退。这两种情况下的疼痛通常是由神经损伤的直接影响或瘫痪和长期固定的结果引起的。疼痛综合征在每种疾病的基础上明确的病理生理。治疗涉及各种药理学和非药理学的方法个性化的每一个特定的疼痛综合征。
Moderate to severe pain is a common feature of central and peripheral demyelinating disorders. Pain in multiple sclerosis tends to occur when the disease is well-established and usually lingers infinitely. Pain in Guillain-Barre syndrome tends to be particularly severe at the time of initial presentation and usually resolves over 8 to 12 weeks. Pain in both conditions is generally caused by either the direct effects of nerve injury or the result of paralysis and prolonged immobilization. Pain syndromes are well-defined in each disorder based on the underlying pathophysiology. Treatment involves a variety of pharmacologic and nonpharmacologic approaches individualized for each specific pain syndrome.