Small-for-size graft in living donor liver transplantation: How far should we go?
Small-for-size graft in living donor liver transplantation: How far should we go?
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DOI：
10.1053/jlts.2003.50198
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发表时间：
2003-09-01
影响因子：
4.6
通讯作者：
Ogawa, K
中科院分区：
文献类型：
--
作者：
Kiuchi, T;Tanaka, K;Ogawa, K
近年来，随着活体肝移植在成人患者中的广泛应用，关于小体积综合征的争议不断升级。尽管有几种症状被认为是该综合征的表现，但小尺寸综合征仍然难以诊断，因为这些症状既不是特异性的，也不是不可避免的。小体积综合征的发生似乎也取决于许多受体和移植物因素。潜在的致病机制包括持续性门脉高压和门脉过度灌注。目前，正在探索几种技术，试图减轻小尺寸综合征的影响。最近的经验表明，小尺寸综合征的发生是多因素的，与小尺寸移植相关的并发症应与各种移植物、受体和技术因素相关。
With the extensive use of living donor liver grafts in adult patients, controversy over small-for-size syndrome has escalated in recent years. Although several symptoms have been suggested as manifestations of the syndrome, small-for-size syndrome remains difficult to diagnose because these symptoms are neither specific nor inevitable. The occurrence of small-for-size syndrome also seems to depend on a number of recipient and graft factors. Potential pathogenic mechanisms include persistent portal hypertension and portal overperfusion. At present, several techniques are being explored in an attempt to ameliorate the impact of small-for-size syndrome. Recent experience suggests that the occurrence of small-for-size syndrome is multifactorial and that complications relating to small-for-size grafts should be examined in relation to a variety of graft, recipient, and technical factors.