Measles vaccination coverage, determinants of delayed vaccination and reasons for non-vaccination among children aged 24-35months in Zhejiang province, China
Measles vaccination coverage, determinants of delayed vaccination and reasons for non-vaccination among children aged 24-35months in Zhejiang province, China
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DOI：
10.1186/s12889-018-6226-7
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发表时间：
2018-11-27
影响因子：
4.5
通讯作者：
Chen, Zhiping
中科院分区：
文献类型：
--
作者：
Hu, Yu;Wang, Ying;Chen, Zhiping
背景：本研究旨在评估两剂麻疹疫苗的覆盖率，并确定延迟接种的决定因素。方法：对1386例24 ~ 35月龄儿童进行聚类调查。收集了人口和社会经济特征以及疫苗接种记录。总体覆盖率定义为在24个月大时接受第一剂麻疹疫苗接种和第二剂麻疹疫苗接种的儿童比例。适龄覆盖率的定义是在相关截止日期后一个月内接种麻疹疫苗的儿童比例。采用Kaplan-Meier分析评估时效性。采用Cox比例风险回归来确定延迟接种疫苗的决定因素。结果：麻疹第一剂疫苗总接种率为96.9%，第二剂疫苗总接种率为93.9%。第一剂和第二剂麻疹疫苗的适龄覆盖率分别为76.6和68.2%。有多于一名子女的家庭、非本地儿童与延迟接种第一剂及第二剂麻疹疫苗有关。家中分娩的儿童、母亲较年轻、母亲受教育程度低、母亲有固定工作和家庭收入低与麻疹第二剂疫苗接种延迟有关。结论：麻疹疫苗第一剂和第二剂的接种率均有所提高，但及时性仍有待提高。我们建议政策制定者在规划工作时更多地关注未接种疫苗的原因和延迟接种疫苗的决定因素，以确保麻疹疫苗的高适龄覆盖率。
Background: This study was aimed to assess the coverage of two doses of measles vaccine and identify the determinants of the delayed vaccination.Methods: A cluster survey among 1386 children aged 24-35months was conducted. Characteristics on demographic and socio-economic and vaccination records was collected. The overall coverage was defined as the proportion of children receiving the first dose of measles vaccination and the second dose of measles vaccination by 24months of age. The age-appropriate coverage was defined as the proportion of children receiving the measles vaccine doses within one month after its relevant due date. Timeliness was evaluated with the Kaplan-Meier analysis. Cox proportional hazard regression was adopted to identify determinants of the delayed vaccination.Results: The overall coverage was 96.9% for the first dose of measles vaccine and 93.9% for the second dose of measles vaccine. The age-appropriate coverage of the first and the second dose of measles vaccine was 76.6 and 68.2%, respectively. Household having more than one child, non-local children were associated with the delayed vaccination for the first and the second dose of measles vaccine. Children delivered at home, younger mothers, low maternal education background, mothers with a fixed job, and low household income were associated with the delayed vaccination for the second dose of measles vaccine.Conclusions: The coverage of measles vaccine had been improved for both the first and the second dose, while the timeliness still needed improvement. We suggested the policy-makers pay more attention to the reasons for non-vaccination and determinants of delayed vaccination when planning efforts to ensure the high age-appropriate coverage of measles vaccination.