Multiorgan autoimmune manifestations associated with thymoma.
Multiorgan autoimmune manifestations associated with thymoma.
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与胸腺瘤相关的多器官自身免疫表现。
DOI：
10.1097/jto.0000000000000324
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Giaccone,Giuseppe
中科院分区：
文献类型：
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作者：
Thomas,Anish;Rajan,Arun;Berman,Arlene;Giaccone,Giuseppe
讨论胸腺瘤相关的自身免疫副肿瘤综合征包括重症肌无力（MG）（见于 30-45% 的患者）、免疫介导的血细胞减少症、低丙种球蛋白血症、神经系统综合征以及较少见的多发性肌炎、肝炎和心肌炎。尽管在胸腺瘤患者中可能发现高达 15% 的自身免疫性累及另一器官系统的 MG，但如本例所示，累及一个以上器官系统的情况很少见。
DISCUSSIONThe spectrum of thymoma-associated auto-immune paraneoplastic syndromes include myasthenia gravis (MG)(seen in 30–45% of patients), immune-mediated cytopenias, hypogammaglobulinemia, neurologic syndromes and less commonly polymyositis, hepatitis, and myocarditis. Although MG with auto-immune involvement of another organ system may be found in up to 15% of patients with thymoma, involvement of more than one organ system, as in this case, is rare.