Multinucleated giant cells
Multinucleated giant cells
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DOI：
10.1097/00062752-200001000-00008
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发表时间：
2000-01-01
影响因子：
3.2
通讯作者：
Anderson, JM
中科院分区：
文献类型：
--
作者：
Anderson, JM
最近的研究，旨在发展一个更好地了解单核细胞衍生的多核巨细胞的形成，功能和生物活性的分子和细胞生物学基础。此外，HIV-1感染的T淋巴细胞合胞体和粘附分子/配体相互作用的意义，这些合胞体的形成进行了说明。白细胞介素-4或白细胞介素-13诱导单核细胞-巨噬细胞融合提供了异物巨细胞形成的模型。另一方面，γ-干扰素诱导单核细胞-巨噬细胞融合为Langhans巨细胞形成提供了一个模型。单核细胞-巨噬细胞粘附和融合以形成异物巨细胞的变化由具有不同表面化学的基底提供。破骨细胞生物学的最新进展已经确定了肿瘤坏死因子-α在调节破骨细胞骨吸收和受体-配体相互作用以及破骨细胞活化的信号通路中的作用。尽管异物巨细胞、Langhans巨细胞和破骨细胞来源于单核细胞或单核细胞祖细胞，但它们形成的方式，无论是由细胞因子、受体还是生物活性诱导，都有显著不同。(C)2000 Lippincott威廉姆斯& Wilkins，Inc.
Recent studies directed toward developing a better understanding of the molecular and cellular biology basis of monocyte-derived multinucleated giant cell formation, function, and biologic activity are presented. In addition, HIV-1-infected T-lymphocyte syncytia and the significance of adhesion molecule/ligand interactions in the formation of these syncytia are described. Interleukin-4 or interleukin-13 induction of monocyte-macrophage fusion provides a model for foreign body giant cell formation. On the other hand, interferon-gamma induction of monocyte-macrophage fusion provides a model for Langhans' giant cell formation. Variations in monocyte-macrophage adhesion and fusion to form foreign body giant cells are provided by substrates with different surface chemistries. Recent advances in osteoclast biology have identified the role of tumor necrosis factor-alpha in regulating osteoclast bone resorption and receptor-ligand interactions and signal pathways for osteoclast activation. Although foreign body giant cells, Langhans' giant cells, and osteoclasts are derived from monocytes or monocyte progenitor cells, the ways in which they are formed, whether induced by cytokines, receptors, or biologic activity, are markedly different. (C) 2000 Lippincott Williams & Wilkins, Inc.