Molecular subtypes and imaging phenotypes of breast cancer.
Molecular subtypes and imaging phenotypes of breast cancer.
复制标题
DOI：
10.14366/usg.16030
复制
发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Cho N
中科院分区：
文献类型：
--
作者：
Cho N
在过去的15年中，基于组织病理学的传统乳腺癌分类已被重组为基于基因表达谱的管腔A型、管腔B型、人表皮生长因子受体2（HER2）和基底样亚型。每种分子亚型都显示出不同的进展风险、对治疗的反应和生存结局。将成像表型与分子亚型联系起来的研究表明，基底样亚型中常见非钙化、相对局限性肿块伴后部声学增强，管腔亚型中常见毛刺状肿块伴边界不清和后部声学阴影，HER2富集亚型中常见多形性钙化。了解分子亚型和成像表型的临床意义可以帮助放射科医生指导精准医学，为患者及其肿瘤特征量身定制药物治疗。
During the last 15 years, traditional breast cancer classifications based on histopathology have been reorganized into the luminal A, luminal B, human epidermal growth factor receptor 2 (HER2), and basal-like subtypes based on gene expression profiling. Each molecular subtype has shown varying risk for progression, response to treatment, and survival outcomes. Research linking the imaging phenotype with the molecular subtype has revealed that non-calcified, relatively circumscribed masses with posterior acoustic enhancement are common in the basal-like subtype, spiculated masses with a poorly circumscribed margin and posterior acoustic shadowing in the luminal subtype, and pleomorphic calcifications in the HER2-enriched subtype. Understanding the clinical implications of the molecular subtypes and imaging phenotypes could help radiologists guide precision medicine, tailoring medical treatment to patients and their tumor characteristics.