LPAR4 establishes a tumour-initiating niche.
LPAR4 establishes a tumour-initiating niche.
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LPAR4 建立了一个肿瘤起始生态位。
DOI：
10.1038/s41556-022-01038-z
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发表时间：
2023
影响因子：
21.3
通讯作者：
Sherman,MaraH
中科院分区：
文献类型：
--
作者：
Arnold,Frank;Sherman,MaraH
在胰腺癌的初始阶段，肿瘤起始细胞对挑战性的生长条件具有抵抗力，但转化后的细胞如何获得抗应激和启动肿瘤的状态仍不清楚。在这里，作者确定了LPAR4诱导纤维连接蛋白产生、癌症干细胞和肿瘤起始利基的信号级联反应。
Tumour-initiating cells are resistant to challenging growth conditions during the initiation of pancreatic cancer, but how transformed cells acquire a stress-resistant, tumour-initiating state remains unclear. Here, the authors identify a signalling cascade in which LPAR4 induces fibronectin production, cancer stemness and a tumour-initiating niche.