A CURRENT REVIEW ON THE BIOLOGY AND TREATMENT OF ARTICULAR CARTILAGE DEFECTS (PART I & PART II)
A CURRENT REVIEW ON THE BIOLOGY AND TREATMENT OF ARTICULAR CARTILAGE DEFECTS (PART I & PART II)
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关节软骨缺陷的生物学和治疗的最新综述（第一部分）
DOI：
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
M. Zheng
中科院分区：
文献类型：
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作者：
C. Willers;D. Wood;M. Zheng
骨软骨损伤主要发生在体力活动的年轻成年男性中。关节软骨和/或软骨下骨的损伤不仅可能导致急性关节疾病，导致骨囊内（滑膜炎）或囊外疼痛，而且还可能在以后的生活中引发关节炎。自世纪以来，这种损伤已被证明难以在临床上治疗，并且许多治疗基本上是姑息性的。过去的治疗方法，如磨损关节成形术、钻孔、微骨折和关节镜灌洗，在清除关节碎屑和促进大多数自体修复机制中使用的纤维蛋白凝块形成方面很有用。然而，这些技术的局限性是它们不能将受损的软骨和软骨下骨恢复到它们的正常组织结构。组织工程的最新进展集中在利用自体软骨细胞移植、生物材料和生长因子促进生物力学表面的再生。
Osteochondral injury occurs predominantly in physically active young adult males. Injury to the articular cartilage and/or subchondral bone may not only cause acute joint disease resulting in osseous intracapsular (synovitis) or extracapsular pain, but may also act to spawn arthritic conditions in later life. Since the 18th century, such injury has proven difficult to treat clinically, and much therapy has been essentially palliative. Past treatments such as abrasion arthroplasty, drilling, microfracture and arthroscopic lavage have been useful in removing articular debris and promoting the formation of the fibrin clot used in most native repair mechanisms. However, the limitation of these techniques is their inability to restore the damaged cartilage and subchondral bone to their normal tissue architecture. Recent developments in tissue engineering have concentrated on the utilization of autologous chondrocyte implantation, biomaterials and growth factors to promote the regeneration of biomechanically su...
影响因子：
3.7
作者：
Johnstone, B;Hering, TM;Yoo, JU
通讯作者：
Yoo, JU
DOI：
10.2106/00004623-199507000-00021
发表时间：
1995-07-01
影响因子：
5.3
作者：
EVANS, CH;ROBBINS, PD
通讯作者：
ROBBINS, PD
DOI：
10.2106/00004623-199304000-00009
发表时间：
1993-04-01
影响因子：
5.3
作者：
SHAPIRO, F;KOIDE, S;GLIMCHER, MJ
通讯作者：
GLIMCHER, MJ