Pa16 AMPHIDINOLIDE C, THE FIRST 25-MEMBERED MACROCYCLIC LACTONE WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE CULTURED DINOFLAGELLATE AMPHIDINIUM SP.
Pa16 AMPHIDINOLIDE C, THE FIRST 25-MEMBERED MACROCYCLIC LACTONE WITH POTENT ANTINEOPLASTIC ACTIVITY FROM THE CULTURED DINOFLAGELLATE AMPHIDINIUM SP.
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Pa16 Amphidinolide C，第一个具有有效抗肿瘤活性的 25 元大环内酯，来自培养的甲藻 Amphidinium SP。
DOI：
10.1002/chin.198818325
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Y. Ohizumi
中科院分区：
文献类型：
--
作者：
J. Kobayashi;M. Ishibashi;H. Nakamura;Y. Hirata;T. Sasaki;Y. Ohizumi
实验室培养甲藻Amphidinium sp.提取物的研究它象征性地与冲绳扁形虫Amphiscolops sp.联系在一起，已导致在分离的amphidinocyte C，第一个25元大环内酯具有强大的抗肿瘤活性。其结构主要是根据波谱数据，特别是几种类型的二维核磁共振谱，包括检测到的杂原子多重键相关法来确定的。与海洋动物共生的微生物是当前自然资源开发或食品卫生问题的研究热点。最近，一些海洋微生物，如细菌，2甲藻，3或蓝藻4已被证明是负责生产的一些海洋天然产物，以前从宿主或高等动物。来自共生甲藻的神经毒素5 - 12345678已被证明是理解细胞兴奋性的分子基础的必要工具。尽管这一领域的研究越来越重要，但共生微生物代谢物的化学性质，
Investigation on the extract of the laboratory cultured dinoflagellateAmphidinium sp., which was symbolically associated with an Okinawan flatworm Amphiscolops sp., has resulted in the isolation of amphidinolide C, the first 25-membered macrocyclic lactone with potent antineoplastic activity. The structure has been elucidated mainly on the basis of spectroscopic data, especially several types of two-dimensional NMR spectra including-detected heteronuclear multiple-bond correlation method.Symbiotic microorganisms associated with marineanimals are of current interest from the development of natural resources or food hygienic problems. Recently some marine microorganisms such as bacteria, 2 dinoflagellates, 3 or cyanophytes4 have been demonstrated to be responsible for the production of some marine natural products previously obtained from host or higher animals. Neurotoxins5" 1 2345678 from symbiotic dinoflagellates have proved to be essential tools in understanding the molecular basis of cellular excitability. 9 In spite of the growing significance of the research in this field, the chemistry of the metabolites of symbiotic mi-