Engineering dextran-based scaffolds for drug delivery and tissue repair.
Engineering dextran-based scaffolds for drug delivery and tissue repair.
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DOI：
10.2217/nnm.12.149
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发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Mao JJ
中科院分区：
文献类型：
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作者：
Sun G;Mao JJ
由于其化学反应性羟基，葡聚糖可以用不同的官能团修饰，形成球形，管状和3D网络结构。开发新型的功能性支架用于有效的控制释放和组织再生一直是主要的研究兴趣，并且为许多疾病提供了有前途的治疗方法。葡聚糖基支架是天然可生物降解的，可以作为许多蛋白质生物分子的生物活性载体。用适当的信号线索重建大规模组织再生支架的体外微环境尚未完全开发，并且仍然是再生医学的重大挑战。本文将介绍近年来在葡聚糖基聚合物和支架的控制释放和组织工程的进展。特别注意的是，以葡聚糖为基础的水凝胶，精确地操纵所需的结构特性和封装与治疗性新血管形成的定义的血管生成生长因子的发展，以及它们的潜力，伤口修复。
Owing to its chemically reactive hydroxyl groups, dextran can be modified with different functional groups to form spherical, tubular and 3D network structures. The development of novel functional scaffolds for efficient controlled release and tissue regeneration has been a major research interest, and offers promising therapeutics for many diseases. Dextran-based scaffolds are naturally biodegradable and can serve as bioactive carriers for many protein biomolecules. The reconstruction of the in vitro microenvironment with proper signaling cues for large-scale tissue regenerative scaffolds has yet to be fully developed, and remains a significant challenge in regenerative medicine. This paper will describe recent advances in dextran-based polymers and scaffolds for controlled release and tissue engineering. Special attention is given to the development of dextran-based hydrogels that are precisely manipulated with desired structural properties and encapsulated with defined angiogenic growth factors for therapeutic neovascularization, as well as their potential for wound repair.