Gene loss and evolutionary rates following whole-genome duplication in teleost fishes
Gene loss and evolutionary rates following whole-genome duplication in teleost fishes
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DOI：
10.1093/molbev/msl049
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发表时间：
2006-09-01
影响因子：
10.7
通讯作者：
Robinson-Rechavi, Marc
中科院分区：
文献类型：
--
作者：
Brunet, Frederic G.;Roest Crollius, Hugues;Robinson-Rechavi, Marc
硬骨鱼为动物谱系中古老的全基因组复制提供了第一个明确的支持。对酵母或植物的研究表明，这种复制的影响可以通过基因保留的复杂模式和进化压力的变化来介导。为了探索这种模式在鱼类，我们已经确定了系统发育分析的进化起源675河豚重复基因分配到染色体，使用其他物种的actinopterygian鱼类的额外数据。在基因组复制后保留在双拷贝中的基因子集在发育、信号传导、行为和调节功能类别中富集。重复鱼类基因的进化速率似乎由3种力量决定：1）鱼类蛋白质比哺乳动物直系同源物进化得更快; 2）基因组重复后保持在双重的基因代表了最强纯化选择下的子集; 3）重复后，在一个旁系同源物中进化速率有不对称的加速。这些结果表明，类似的机制是在鱼类酵母或植物的工作，并提供了一个框架，为未来的调查在鱼类和其他动物复制的后果。
Teleost fishes provide the first unambiguous support for ancient whole-genome duplication in an animal lineage. Studies in yeast or plants have shown that the effects of such duplications can be mediated by a complex pattern of gene retention and changes in evolutionary pressure. To explore such patterns in fishes, we have determined by phylogenetic analysis the evolutionary origin of 675 Tetraodon duplicated genes assigned to chromosomes, using additional data from other species of actinopterygian fishes. The subset of genes, which was retained in double after the genome duplication, is enriched in development, signaling, behavior, and regulation functional categories. The evolutionary rate of duplicate fish genes appears to be determined by 3 forces: 1) fish proteins evolve faster than mammalian orthologs; 2) the genes kept in double after genome duplication represent the subset under strongest purifying selection; and 3) following duplication, there is an asymmetric acceleration of evolutionary rate in one of the paralogs. These results show that similar mechanisms are at work in fishes as in yeast or plants and provide a framework for future investigation of the consequences of duplication in fishes and other animals.