Cellular systems for epithelial invagination.
Cellular systems for epithelial invagination.
复制标题
DOI：
10.1098/rstb.2015.0526
复制
发表时间：
2017-05-19
期刊：
影响因子：
--
通讯作者：
Green JB
中科院分区：
文献类型：
--
作者：
Pearl EJ;Li J;Green JB
上皮内陷是形态发生的基本模块，其反复发生以产生发育有机体的许多部分的结构。通过改变细胞群体的物理性质，例如形状和/或位置，内陷驱动从原肠胚形成期间重新配置整个身体轴到器官发生期间形成眼睛，耳朵和多个导管和腺体的原基的过程。内陷所需的上皮弯曲是通过涉及细胞系统的各种机制实现的。在这里，我们提供了一个不同的机制，其中一些可以结合起来工作，并概述了它们适用的情况。这篇文章是“系统形态动力学：了解组织硬件的发展”主题的一部分。
Epithelial invagination is a fundamental module of morphogenesis that iteratively occurs to generate the architecture of many parts of a developing organism. By changing the physical properties such as the shape and/or position of a population of cells, invagination drives processes ranging from reconfiguring the entire body axis during gastrulation, to forming the primordia of the eyes, ears and multiple ducts and glands, during organogenesis. The epithelial bending required for invagination is achieved through a variety of mechanisms involving systems of cells. Here we provide an overview of the different mechanisms, some of which can work in combination, and outline the circumstances in which they apply. This article is part of the themed issue ‘Systems morphodynamics: understanding the development of tissue hardware’.