The white blood cell count is an independent predictor of no‐reflow and mortality following acute myocardial infarction in the coronary interventional era
The white blood cell count is an independent predictor of no‐reflow and mortality following acute myocardial infarction in the coronary interventional era
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DOI：
10.1080/07853890310021553
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发表时间：
2004-01
影响因子：
4.4
通讯作者：
S. Kojima;T. Sakamoto;M. Ishihara;K. Kimura;Shunichi Miyazaki;C. Tei;H. Hiraoka;M. Sonoda;K. Tsuchihashi;M. Yamagishi;Takeshi Inoue;Y. Asada;Y. Ikeda;M. Shirai;H. Ogawa
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文献类型：
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作者：
S. Kojima;T. Sakamoto;M. Ishihara;K. Kimura;Shunichi Miyazaki;C. Tei;H. Hiraoka;M. Sonoda;K. Tsuchihashi;M. Yamagishi;Takeshi Inoue;Y. Asada;Y. Ikeda;M. Shirai;H. Ogawa
背景在使用冠状动脉再灌注治疗之前的时代，白色血细胞（WBC）计数升高与急性心肌梗死（AMI）后不良事件的风险较高相关。然而，自冠状动脉介入治疗引入以来，尚未研究AMI后WBC计数与预后的关系。目标。评价急性心肌梗死（AMI）发作后48小时内高白细胞计数是否可预测接受经皮冠状动脉介入治疗（PCI）患者未来的不良事件。法我们使用日本急性冠脉综合征研究（JACSS）数据库评价了1,016例在MI急性期接受PCI的患者。结果WBC计数与吸烟、突发AMI和PCI期间无复流现象显著相关，年龄、肌酸激酶峰值水平和Killip分级也是如此。WBC计数升高与院内死亡风险升高显著相关。白细胞计数最高四分位数的患者AMI后预后不良的可能性是最低四分位数的患者的三倍。结论.白细胞计数对于患者风险分层具有重要意义，并且可以用作预测AMI任何治疗后未来不良事件的通用标志物。
BACKGROUND. In the era before the use of coronary reperfusion therapy, an elevated white blood cell (WBC) count was associated with a higher risk of adverse events following acute myocardial infarction (AMI). However, the relationship between WBC count and prognosis after AMI has not been investigated since coronary intervention was introduced. AIM. To evaluate whether a high WBC count within 48 hours of the onset of AMI predicts future adverse events in patients undergoing percutaneous coronary intervention (PCI). METHOD. We evaluated 1,016 patients who underwent PCI in the acute phase of MI using the Japanese Acute Coronary Syndrome Study (JACSS) database. RESULTS. WBC count was significantly associated with smoking, sudden onset AMI, and the no‐reflow phenomenon during PCI, as were age, peak creatine kinase level, and Killip class. An elevated WBC count was significantly associated with higher risk of in‐hospital mortality. Patients in the highest quartile of WBC count were about three times more likely to have a poor prognosis after AMI compared to those in the lowest quartile. CONCLUSIONS. The WBC count is of great significance for stratifying patient risk and can be used as a universal marker for predicting future adverse events following any treatment for AMI.