Generalized growth retardation in rats induced by prenatal exposure to methylazoxymethyl acetate.
Generalized growth retardation in rats induced by prenatal exposure to methylazoxymethyl acetate.
复制标题
产前暴露于乙酸甲基偶氮甲酯引起的大鼠普遍生长迟缓。
DOI：
10.1002/tera.1420050212
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发表时间：
1972
期刊：
影响因子：
--
通讯作者：
H. Waisman
中科院分区：
文献类型：
--
作者：
M. Fischer;C. Welker;H. Waisman
在妊娠第13至18天单次注射醋酸甲偶氮甲酯可延缓后代的一般出生后发育，并导致小脑畸形。当在妊娠第14或15天给予化合物时，影响最严重。在35日龄时，身体、脑、肾、肝、脾和睾丸重量显著降低，而在14日龄时，仅脑重量显著低于对照组。大脑是唯一表现出宏观畸形的器官，其特征是大脑半球大大缩小和皮质套缺陷。此外，整个端脑、间脑、中脑和小脑的核群和纤维束的尺寸都缩小了。
Single injections to rats of methylazoxymethyl acetate on days 13 to 18 of gestation retarded the general postnatal development of the offspring and resulted in micrencephaly. The effects were most severe when the compound was administered on day 14 or 15 of gestation. At 35 days of age, body, brain, kidney, liver, spleen, and testis weights were significantly reduced, whereas at 14 days of age only the brain weights were significantly less than controls. The brain was the only organ that showed macroscopic malformations, characterized by greatly reduced cerebral hemispheres and defects in the cortical mantle. In addition, nuclear groups and fiber tracts throughout the telencephalon, diencephalon, midbrain, and cerebellum were reduced in size.