Cognitive behavioral therapy for depression among adults in Japanese clinical settings: a single-group study.
Cognitive behavioral therapy for depression among adults in Japanese clinical settings: a single-group study.
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DOI：
10.1186/1756-0500-3-160
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发表时间：
2010-06-07
影响因子：
1.8
通讯作者：
Ono Y
中科院分区：
文献类型：
--
作者：
Fujisawa D;Nakagawa A;Tajima M;Sado M;Kikuchi T;Hanaoka M;Ono Y
认知行为疗法（CBT）治疗日本抑郁症患者的经验支持是缺乏的，因此，CBT治疗抑郁症在日本的临床环境中的可行性研究是迫切需要的。一个文化适应，16周的手工制作的个人CBT计划，为日本重度抑郁症患者开发。共27例重性抑郁症患者参加了一项单组研究，目的是检验该方案的可行性。26例患者（96%）完成了研究。所有患者（意向治疗样本）的贝克抑郁量表-II（BDI-II）的平均总分从32.6改善至11.7，平均变化为20.8（95%置信区间：17.0至24.8）。终点评估时的组内效应量为2.64（Cohen's d）。21例患者（77.7%）显示治疗反应，17例患者（63.0%）在方案结束时达到缓解。在主观和客观抑郁严重程度的测量中观察到显着改善（采用BDI-II、抑郁症状自评快速量表和汉密尔顿抑郁量表评估），功能失调态度（通过功能失调态度量表评估），整体功能（通过DSM-4的全球功能评估进行评估）和主观幸福感（通过WHO主观幸福感量表评估）（所有p值< 0.001）。我们的手动治疗包括一个16周的个人CBT计划的抑郁症似乎是可行的，并可能实现良好的治疗结果，日本患者的抑郁症。进一步的研究，涉及更大的随机，对照试验设计的样本是必要的。UMIN-CTR UMIN000002542.
Empirical support for cognitive behavioral therapy (CBT) for treating Japanese patients with major depression is lacking, therefore, a feasibility study of CBT for depression in Japanese clinical settings is urgently required. A culturally adapted, 16-week manualized individual CBT program for Japanese patients with major depressive disorder was developed. A total of 27 patients with major depression were enrolled in a single-group study with the purpose of testing the feasibility of the program. Twenty six patients (96%) completed the study. The mean total score on the Beck Depression Inventory-II (BDI-II) for all patients (Intention-to-treat sample) improved from 32.6 to 11.7, with a mean change of 20.8 (95% confidence interval: 17.0 to 24.8). Within-group effect size at the endpoint assessment was 2.64 (Cohen's d). Twenty-one patients (77.7%) showed treatment response and 17 patients (63.0%) achieved remission at the end of the program. Significant improvement was observed in measurement of subjective and objective depression severity (assessed by BDI-II, Quick Inventory of Depressive Symptomatology-Self Rated, and Hamilton Depression Rating Scale), dysfunctional attitude (assessed by Dysfunctional Attitude Scale), global functioning (assessed by Global Assessment of Functioning of DSM-IV) and subjective well-being (assessed by WHO Subjective Well-being Inventory) (all p values < 0.001). Our manualized treatment comprised of a 16-week individual CBT program for major depression appears feasible and may achieve favorable treatment outcomes among Japanese patients with major depression. Further research involving a larger sample in a randomized, controlled trial design is warranted. UMIN-CTR UMIN000002542.