Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders
Somatic referral of visceral sensations and rectal sensory threshold for pain in children with functional gastrointestinal disorders
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DOI：
10.1016/j.jpeds.2006.08.072
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发表时间：
2007-01-01
影响因子：
5.1
通讯作者：
Wieckowska, Anna
中科院分区：
文献类型：
--
作者：
Faure, Christophe;Wieckowska, Anna
Objective.检验与功能性胃肠道疾病相关的腹痛与内脏高敏感性和内脏感觉异常感知相关的假设。研究设计。我们对35名符合罗马11项标准的肠易激综合征（IBS; n = 21）、功能性腹痛（FAP; n = 8）或功能性消化不良（FD; n = 6）儿童（10-17.6岁）进行了检查，并与10名对照受试者（10.2-16.1岁）进行了比较。所有患者均接受直肠恒压器检查。在人体图上报告了疼痛感。结果直肠感觉痛阈值（RSTP）在直肠扩张后的感觉投射、直肠感觉痛阈值（RSTP）及直肠感觉痛阈值的诊断价值。直肠扩张引起的感觉投射到S3皮节在对照组和FD和异常网站在IBS和FAP的儿童。与对照组相比，IBS和FAP儿童的RSTP降低（P <0.002），FD儿童与对照组相比无差异。在30.8 mm Hg时，对照组的第5百分位数RSTP诊断IBS和FAP的敏感性为89%，特异性为83%。IBS和FAP儿童的特征是直肠超敏反应和直肠扩张后的异常疼痛。
Objective. To test the hypothesis that abdominal pain related to functional gastrointestinal disorders is associated with visceral hypersensitivity and abnormal perception of visceral sensations.Study design. We examined 35 children (10-17.6 years old) fulfilling the Rome 11 criteria with irritable bowel syndrome (IBS; n = 21), functional abdominal pain (FAP; n = 8) or functional dyspepsia (FD; n = 6) compared with 10 control subjects (10.2-16.1 years). All underwent a rectal barostat examination. Painful sensations were reported on a human body diagram. The projections of sensations induced by rectal distension, the rectal sensory threshold for pain (RSTP) and the diagnostic value of RSTP measurements were measured.Results. Rectal distension induced sensations that projected to the S3 dermatome in the control subjects and FD and to aberrant sites in children with IBS and FAP. The RSTP was decreased in children with IBS and FAP compared with control subjects (P < .002) and was not different in children with FD compared with control subjects. At 30.8 mm Hg, the 5th percentile for the control subjects the RSTP had a sensitivity rate of 89% and a specificity rate of 83% for IBS and FAP diagnosis.Conclusion. Children with IBS and FAP are characterized by the association of rectal hypersensitivity and abnormal pain referral after rectal distension.