Breast cancer in pregnancy
Breast cancer in pregnancy
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DOI：
10.1016/s0140-6736(11)61092-1
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发表时间：
2012-02-11
期刊：
影响因子：
168.9
通讯作者：
Van Calsteren, Kristel
中科院分区：
文献类型：
--
作者：
Amant, Frederic;Loibl, Sibylle;Van Calsteren, Kristel
乳腺癌的分期和治疗在怀孕期间是可能的，应该在多学科的背景下确定。肿瘤生物学、肿瘤分期和诊断时的妊娠期决定了合适的方法。在怀孕的所有三个月里，乳腺癌手术都是可能的。在怀孕期间可以进行放射治疗，但根据胎儿接受的剂量，可能导致胎儿预后不良。放射治疗的决定应根据个人情况而定。越来越多的证据支持从妊娠14周开始进行化疗。新的乳腺癌治疗方法可能适用于怀孕患者，但他莫昔芬和曲妥珠单抗在怀孕期间是禁忌。怀孕期间的癌症治疗将减少早期分娩的需要，从而减少早产，这是孕期乳腺癌管理的一个主要问题。
Breast cancer staging and treatment are possible during pregnancy, and should be defined in a multidisciplinary setting. Tumour biology, tumour stage, and gestational stage at diagnosis determine the appropriate approach. Surgery for breast cancer is possible during all trimesters of pregnancy. Radiotherapy is possible during pregnancy but, dependent on the fetal dose received, can result in poor fetal outcomes. The decision to give radiotherapy should be made on an individual basis. Evidence increasingly supports administration of chemotherapy from 14 weeks' gestation onwards. New breast cancer treatments might be applicable to pregnant patients, but tamoxifen and trastuzumab are contraindicated during pregnancy. Cancer treatment during pregnancy will decrease the need for early delivery and thus prematurity, which is a major concern in management of breast cancer in pregnancy.