Nutrition and the psychoneuroimmunology of postpartum depression.
Nutrition and the psychoneuroimmunology of postpartum depression.
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DOI：
10.1017/s0954422412000091
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发表时间：
2012-06
影响因子：
5.7
通讯作者：
Corwin, E. J.
中科院分区：
文献类型：
--
作者：
Ellsworth-Bowers, E. R.;Corwin, E. J.
产后抑郁(PPD)是一种相对常见且往往严重的情绪障碍，发生在女性分娩后。PPD的病因尚不清楚，尽管有新的证据表明PPD与心理神经免疫有关。此外，还涉及n-3多不饱和脂肪酸、维生素B、维生素D和微量矿物质的缺乏。本文综述了微量营养素状态与产后抑郁之间联系的证据，分析了每种微量营养素对产后抑郁心理神经免疫机制的潜在贡献。综述了有关PPD与妇女n-3多不饱和脂肪酸、维生素B、维生素D及微量元素锌、硒水平的文献。研究结果表明，虽然n-3多不饱和脂肪酸水平已被证明与产后抑郁呈负相关，并与精神神经免疫学有关，但关于n-3多不饱和脂肪酸预防或治疗产后抑郁的能力，有混合的证据。维生素B的状态与产后抑郁的关系并不明显，尽管在非围产期人群中，它似乎与抑郁症成反比，并可能对免疫力产生影响。通过有趣但规模较小的研究，维生素D和微量矿物质锌和硒与产后抑郁和精神神经免疫学有关。总体而言，有证据表明，某些微量营养素缺乏可能通过心理神经免疫机制导致产后抑郁的发生。更好地了解这些机制对于指导未来关于PPD的研究、临床实践和健康教育具有重要意义。
Postpartum depression (PPD) is a relatively common and often severe mood disorder that develops in women after childbirth. The aetiology of PPD is unclear, although there is emerging evidence to suggest a psychoneuroimmune connection. Additionally, deficiencies in n-3 PUFA, B vitamins, vitamin D and trace minerals have been implicated. This paper reviews evidence for a link between micronutrient status and PPD, analysing the potential contribution of each micronutrient to psychoneuroimmunological mechanisms of PPD. Articles related to PPD and women’s levels of n-3 PUFA, B vitamins, vitamin D and the trace minerals Zn and Se were reviewed. Findings suggest that while n-3 PUFA levels have been shown to vary inversely with PPD and link with psychoneuroimmunology, there is mixed evidence regarding the ability of n-3 PUFA to prevent or treat PPD. B vitamin status is not clearly linked to PPD, even though it seems to vary inversely with depression in non-perinatal populations and may have an impact on immunity. Vitamin D and the trace minerals Zn and Se are linked to PPD and psychoneuroimmunology by intriguing, but small, studies. Overall, evidence suggests that certain micronutrient deficiencies contribute to the development of PPD, possibly through psychoneuroimmunological mechanisms. Developing a better understanding of these mechanisms is important for guiding future research, clinical practice and health education regarding PPD.