Medical microbiological approach to Archaea in oral infectious diseases
Medical microbiological approach to Archaea in oral infectious diseases
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DOI：
10.1016/j.jdsr.2013.01.002
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发表时间：
2013-05
影响因子：
6.6
通讯作者：
H. Maeda;Kimito Hirai;Junji Mineshiba;Tadashi Yamamoto;S. Kokeguchi;S. Takashiba
中科院分区：
文献类型：
--
作者：
H. Maeda;Kimito Hirai;Junji Mineshiba;Tadashi Yamamoto;S. Kokeguchi;S. Takashiba
分子生物学技术的最新进展已经产生了大量关于口腔菌群的信息。微生物群落被证明比以前认为的更加多样化，并且包括许多以前未表征的微生物。与口腔疾病相关的微生物的研究目标范围已经扩大到包括这些未知或未表征的微生物。这些生物包括古生菌。最近的一系列报告表明，这些微生物可能是牙周炎和根尖牙周炎的潜在病原体，主要基于它们在患病部位的检测频率或数量增加与疾病的严重程度或症状相关。然而，不能根据这些间接证据得出古菌是口腔病原体的结论。需要进一步研究这些生物的潜在致病机制。这将需要调查古细菌的抗原性以及与其他已确定的口腔病原体的协同作用。特别是，对宿主免疫反应的研究将提供对古菌作为疑似病原体的医学影响的见解。
Recent advances in molecular biological techniques have yielded large amounts of information regarding the oral microflora. The microbiological communities were shown to be more diverse than previously thought and to include a number of previously uncharacterized microorganisms. The range of research targets of microorganisms associated with oral diseases has been expanded to include these unknown or uncharacterized organisms. These organisms include the Archaea. A series of recent reports suggested these microorganisms to be potential pathogens involved in periodontitis and apical periodontitis mainly based on the detection frequency or their increased numbers in diseased sites in association with the severity or symptoms of disease. However, it cannot be concluded that Archaea are oral pathogens based on such circumstantial evidence. Further studies are required to investigate the potential pathogenic mechanisms of action of these organisms. This will require investigation of the antigenic properties of the Archaea and synergism with other established oral pathogens. Especially, studies of the host immune response will provide insight into the medical impact of Archaea as suspected pathogens.