A population study of plasma neuropeptide Y: Correlations with components of the metabolic syndrome
A population study of plasma neuropeptide Y: Correlations with components of the metabolic syndrome
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DOI：
10.3109/08037059609078073
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发表时间：
1996-01-01
期刊：
影响因子：
1.8
通讯作者：
Ohman, K. Peter
中科院分区：
文献类型：
--
作者：
Nystrom, Fredrik;Nilsson, Peter;Ohman, K. Peter
为了研究神经肽Y （NPY）与年龄、性别、血压（BP）、心血管疾病危险因素和肾素血管紧张素系统之间的关系，我们随机选择220名受试者（49%为男性）进行了一项基于人群的研究。排除正在接受抗高血压治疗的受试者，参与率为67%。空腹状态下于08.00 h抽取静脉血，安装Spacelab 90202/90207动态血压测定仪。血浆NPY水平呈正态分布，平均水平为144 +- 17 pmol/L（平均值+- SD）。女性的水平有高于男性的趋势（分别为147 +- 17 pmol/L和142 +- 17 pmol/L， p = 0.053）。无论男女，NPY与动态血压或临床血压均无相关性。血管紧张素II在男性中与NPY呈正相关，而在女性中无相关（r = 0.27, p = 0.007）。无论男女，NPY与体重指数、腰臀比、血压或c肽均无相关性。总胆固醇（r = 0.39, p = 0.0001）和低密度脂蛋白胆固醇（r = 0.35, p = 0.0001）与NPY仅在女性中呈正相关。以血浆总胆固醇或LDL-胆固醇作为年龄之后的第二大自变量，以NPY作为因变量（总胆固醇：标准化r = 0.43, p = 0.0002， LDL-胆固醇：标准化r = 0.34, p = 0.002）进行多元回归分析，相关性保持不变。结论：女性低密度脂蛋白胆固醇与NPY呈正相关，与年龄和代谢综合征成分无关，可能是一种性别特异性心血管危险标志物。
To study the relations between neuropeptide Y (NPY) and age, gender, blood pressure (BP) and risk factors for cardiovascular disease and the renin-angiotensin system, we performed a population-based study through random selection of 220 subjects (49% men). Subjects on antihypertensive therapy were excluded and participation rate was 67%. Venous blood was drawn at 08.00 h in the fasting state and a Spacelab 90202/90207 ambulatory BP device was then fitted. Plasma NPY levels were normally distributed and the mean level was 144 +- 17 pmol/L (mean +- SD). There was a trend towards higher levels in women than in men (147 +- 17 pmol/L and 142 +- 17 pmol/L, respectively, p = 0.053). No correlations were found between NPY and ambulatory BP or clinic BP in either gender. Angiotensin II correlated positively with NPY in men but not in women (r = 0.27, p = 0.007). There were no correlations between NPY and body mass index, waist/hip ratio, BP or C-peptide in either gender. Total cholesterol (r = 0.39, p lt 0.0001) and LDL-cholesterol (r = 0.35, p = 0.0001) were positively correlated with NPY in women only. The correlation remained in multiple regression analysis with plasma total or LDL- cholesterol as second independent variable to age, and NPY as dependent variable (total cholesterol: standardized r = 0.43, p = 0.0002, LDL-cholesterol: standardized r = 0.34, p = 0.002, respectively). Conclusion: The positive correlation between LDL-cholesterol and NPY in women, independent of age, and components of the metabolic syndrome, makes it a possible gender-specific cardiovascular riskmarker.