Heterogeneity of eye drop use among symptomatic dry eye individuals in Japan: large-scale crowdsourced research using DryEyeRhythm application
Heterogeneity of eye drop use among symptomatic dry eye individuals in Japan: large-scale crowdsourced research using DryEyeRhythm application
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DOI：
10.1007/s10384-020-00798-1
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发表时间：
2021-01-07
影响因子：
2.4
通讯作者：
Kobayashi, Hiroyuki
中科院分区：
文献类型：
--
作者：
Eguchi, Atsuko;Inomata, Takenori;Kobayashi, Hiroyuki
目的 确定眼药水类型和使用频率，并调查日本有症状干眼 (DE) 患者不使用眼药水的风险因素。研究设计众包观察性研究。方法本研究于 2016 年 11 月至 2019 年 9 月期间使用 DryEyeRhythm 智能手机应用程序进行。收集的数据包括眼药水使用类型和频率、人口统计、病史、生活方式和自我报告症状。有症状的 DE 被定义为眼表疾病指数总分≥13。使用多变量逻辑回归分析确定了不使用滴眼剂的危险因素。结果 在 2619 名有症状的 DE 个体中，1876 人没有使用滴眼剂。最常见的滴眼剂类型是人工泪液（53.4%），其次是0.1%透明质酸（33.1%）和3%地夸磷索钠（18.7%）。不使用滴眼剂的危险因素（比值比[95%置信区间]）包括年龄（0.97 [0.97-0.98]）、体重指数（1.04 [1.01-1.07]）、脑部疾病（0.38 [0.15-0.98]）、胶原蛋白疾病（0.30 [0.13-0.68]）、抑郁症和精神分裂症以外的精神疾病(0.65 [0.45-0.93])、白内障手术 (0.12 [0.02-0.59])、白内障以外的眼科手术和激光辅助原位角膜磨镶术 (0.55 [0.34-0.88])、当前 (0.47 [0.38-0.57]) 或过去 (0.58 [0.43-0.77])使用隐形眼镜、>8 小时屏幕暴露时间 (1.38 [1.05-1.81])、9 小时 (1.34 [1.04-1.72]) 睡眠时间和饮水量 (0.97 [0.94-0.98])。 结论 许多患有症状性 DE 的参与者没有使用优化的滴眼剂治疗，并确定了不使用滴眼剂的风险因素。 DryEyeRhythm 应用程序可能有助于改善 DE 治疗。
Purpose To determine eye drop type and usage frequency and investigate risk factors for no eye drop use in individuals with symptomatic dry eye (DE) in Japan.Study design Crowdsourced observational study.Methods This study was conducted using the DryEyeRhythm smartphone application between November 2016 and September 2019. Data collected included the type and frequency of eye drop use, demographics, medical history, lifestyle, and self-reported symptoms. Symptomatic DE was defined as an Ocular Surface Disease Index total score of >= 13. Risk factors for no eye drop use were identified using multivariate logistic regression analyses.Results Among 2619 individuals with symptomatic DE, 1876 did not use eye drops. The most common eye drop type was artificial tears (53.4%), followed by hyaluronic acid 0.1% (33.1%) and diquafosol sodium 3% (18.7%). Risk factors (odds ratio [95% confidence interval]) for no eye drop use were age (0.97 [0.97-0.98]), body mass index (1.04 [1.01-1.07]), brain disease (0.38 [0.15-0.98]), collagen disease (0.30 [0.13-0.68]), mental illness other than depression and schizophrenia (0.65 [0.45-0.93]), cataract surgery (0.12 [0.02-0.59]), ophthalmic surgery other than cataract and laser-assisted in situ keratomileusis (0.55 [0.34-0.88]), current (0.47 [0.38-0.57]) or past (0.58 [0.43-0.77]) contact lens use, >8 h screen exposure time (1.38 [1.05-1.81]), 9 h (1.34 [1.04-1.72]) sleep time, and water intake (0.97 [0.94-0.98]).Conclusion Many participants with symptomatic DE did not use optimized eye drop treatment and identified risk factors for no eye drop use. The DryEyeRhythm application may help improve DE treatment.