Exposure to benzene and risk of leukemia among shoe factory workers
Exposure to benzene and risk of leukemia among shoe factory workers
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DOI：
10.5271/sjweh.704
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发表时间：
2003-02-01
影响因子：
6.3
通讯作者：
Zappa, M
中科院分区：
文献类型：
--
作者：
Costantini, AS;Quinn, M;Zappa, M
目的本研究试图增加多年的后续行动，以早期的研究描述过量白血病工人暴露于苯为基础的胶水在一家鞋厂，并进行定量暴露评估苯的暴露和白血病的风险。方法该队列包括1687人完整的工作历史，在1950年1月1日的工作，并遵循到1999年12月31日。对于每个受试者，特定时间的累积暴露（ppm-年）计算为苯的特定工作浓度（ppm）和每个工作的持续时间（年）的乘积之和。标准化死亡率（SMR）估计使用国家和地区的具体性别，年龄和periods.Results的累积暴露范围从0到>500 ppm-年率。除最低暴露类别外，所有男性和女性合并的所有血液淋巴细胞生成性恶性肿瘤和白血病的SMR值均升高。白血病风险在最高暴露类别中显着升高，在男性中最明显。男性的SMR值为1.4 [95%置信区间（95% CI）0.2-5.0]，3.7（95% CI 0.1-20.6），3.0（95% CI 0.4-10.9）和7.0（95% CI 1.9-18.0）苯，累积暴露等于200 ppm-年，结论该厂工人白血病死亡率与苯接触有关，且随累积接触量的增加而增加。由于研究规模较小，这些发现对估计低得多的风险的相关性有限。
Objectives The study attempted to add years of follow-up to an earlier study describing excess leukemia among workers exposed to benzene-based glues in a shoe-factory and to conduct a quantitative exposure assessment of the exposure to benzene and the risk of leukemia.Methods The cohort comprised 1687 persons with complete work histories, at work on 1 January 1950, and followed through 31 December 1999. For each subject, time-specific cumulative exposure (ppm-years) was calculated as the sum of the products of job-specific concentrations of benzene (ppm) and the duration (years) for each job. Standardized mortality ratios (SMR) were estimated using national and regional rates specific for gender, age, and period.Results The cumulative exposure ranged from 0 to >500 ppm-years. The SMR values for all hematolymphopoietic malignancies and leukemia for the men and women combined were elevated in all but the lowest exposure category. Leukemia risk was significantly elevated in the highest exposure category and the most evident among the men. The SMR values for the men were 1.4 [95% confidence interval (95% CI) 0.2-5.0], 3.7 (95% CI 0.1-20.6), 3.0 (95% CI 0.4-10.9), and 7.0 (95% CI 1.9-18.0) for benzene, the cumulative exposure equaling 200 ppm-years, respectively.Conclusions The results indicate that leukemia mortality is associated with exposure to benzene in this factory and that the risk increases with increasing cumulative exposure. The relevance of these findings for estimating risk at much lower levels is limited because of the small study size.