The beaded filament of the eye lens: An unexpected key to intermediate filament structure and function
The beaded filament of the eye lens: An unexpected key to intermediate filament structure and function
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DOI：
10.1016/0962-8924(96)20001-7
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发表时间：
1996-04-01
影响因子：
19
通讯作者：
Prescott, AR
中科院分区：
文献类型：
--
作者：
Quinlan, RA;Carter, JM;Prescott, AR
1959 年，人们在眼睛的晶状体中描述了一种不寻常的丝状聚合物，现在称为珠状丝。珠状丝的组成蛋白质、组装特性和功能一直难以捉摸。最近公布的两种主要晶状体丝蛋白（CP49 和 filensin）的序列以及与珠状丝状体非常相似的结构的体外重建表明，珠状丝状体在结构上与中间丝状体（IF）相关。晶状体伴侣、α-晶状体蛋白与细丝的结合有助于形成特征性的珠状形态，并为晶状体中这种不寻常的细丝的功能提供重要线索。最近的结果对 IF 功能和组装有几个影响。
In 1959, an unusual filamentous polymer, now called the beaded filament, was described in the lens of the eye. The constituent proteins, assembly properties and functions of the beaded filament have been elusive. The recent publication of the sequences for two major lens filament proteins (CP49 and filensin) and the reconstitution in vitro of structures closely resembling beaded filaments, suggests that the beaded filament is related structurally to intermediate filaments (IFs). The association of the lenticular chaperones, the alpha-crystallins, with the filament contributes to the characteristic beaded morphology, as well as giving important clues to the function of this unusual filament in the lens. The recent results have several implications for IF function and assembly.