Childhood growth and exposure to dichlorodiphenyl dichloroethene and polychlorinated biphenyls
Childhood growth and exposure to dichlorodiphenyl dichloroethene and polychlorinated biphenyls
复制标题
DOI：
10.1067/mpd.2002.120764
复制
发表时间：
2002-01-01
影响因子：
5.1
通讯作者：
Kruse, H
中科院分区：
文献类型：
--
作者：
Karmaus, W;Asakevich, S;Kruse, H
目的：二氯二苯二氯乙烯（DDE）和多氯联苯（PCB）是已知在环境中持久存在的有毒污染物，可能会影响生长。我们调查了从出生到10岁的增长是否与8岁时DDE和PCB的血液浓度有关。研究设计：我们对343名德国儿童进行了双盲随访。1995年测定了DDE和PCB的血液浓度。身高测量是在1994年至1997年之间前瞻性地进行的，并从每个儿童的健康卡中回顾性地获得。重复测量的线性回归模型，控制混杂因素，被applied.Results：增长显着减少了平均1.8厘米（P 0.44 μ g/L的全血）相比，女孩在最低的四分位数（0.08-0.2 μ g/L）。在男孩中没有观察到DDE对生长的影响。PCB血液浓度没有相关的增长减少，无论是女孩还是boy.Conclusions：背景水平浓度DDE，但不PCB，在儿童时期与一个小的减少，女孩的增长明显通过8岁。观察到的差异在第9年考试时缩小，在第10年考试时消失。没有观察到对男孩身高的影响。
Objectives: Dichlorodiphenyl dichloroethene (DDE) and polychlorinated biphenyls (PCB), toxic contaminants known to be persistent in the environment, may affect growth. We investigated whether growth from birth to 10 years of age is associated with blood concentrations of DDE and PCB taken at 8 years of age.Study design: We ambispectively followed up a cohort of 343 German children. DDE and PCB blood concentrations were determined in 1995. Height measurements were conducted prospectively between 1994 and 1997 and obtained retrospectively from each Child's Health Card. Linear regression models for repeated measurements, controlling for confounding factors, were applied.Results: Growth was significantly reduced by an average of 1.8 cm (P .44 mug/L in whole blood) compared with girls in the lowest quartile (0.08-0.2 mug/L). There was no observed growth effect of DDE in boys. PCB blood concentrations were not related to growth reduction in either girls or boys.Conclusions: Background level concentrations to DDE, but not PCB, during childhood are associated with a small reduction in growth for girls evident through the age of 8 years. The observed differences narrow at the year 9 examination and disappear at the year 10 examination. No effects on boys' heights were observed.