Quantitative and qualitative changes in lipids, lipoproteins, apolipoprotein A‐I, and sex hormone‐binding globulin due to two doses of conjugated equine estrogen with and without a progestin
Quantitative and qualitative changes in lipids, lipoproteins, apolipoprotein A‐I, and sex hormone‐binding globulin due to two doses of conjugated equine estrogen with and without a progestin
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两剂含和不含孕激素的结合马雌激素导致脂质、脂蛋白、载脂蛋白 A-I 和性激素结合球蛋白的定量和定性变化
DOI：
10.1016/0020-7292(94)90487-1
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发表时间：
1994
影响因子：
3.8
通讯作者：
Robert J. Stillman
中科院分区：
文献类型：
--
作者：
Valery T. Miller;R. Muesing;John C. LaRosa;D. B. Stoy;Sarah E. Fowler;Robert J. Stillman
目的：探讨马结合雌激素（conjugated equestrogen，COEER）对脂蛋白的定量和定性影响。方法：将103名绝经后妇女随机分为对照组和两组，分别给予0.625 mg和1.25 mg结合雌激素4个月，然后给予相同剂量的雌激素加环甲羟孕酮8个月。01)高密度脂蛋白（HDL）胆固醇、载脂蛋白AI、所有脂蛋白的甘油三酯水平和性激素结合球蛋白能力。在雌激素组中，周期性添加雀黄素可降低HDL胆固醇（P<0.01）和载脂蛋白AI（P<0.05），但对LDL胆固醇无影响。0.625 mg剂量的雌激素可显著降低HDL胆固醇（P<0.05）。雌激素诱导的甘油三酯富集的HDL和LDL是不逆转的resistestin.Conclusion：之间的剂量的共轭马雌激素之前或之后的醋酸甲羟孕酮给药的脂蛋白水平的唯一显着的定量差异是一个更大的下降HDL胆固醇水平与低剂量后4个月的resistestin。这种差异并没有随着时间的推移而持续下去。雌激素诱导的甘油三酯富集脂蛋白的剂量之间没有差异，并且这些定性变化不受雌激素的影响。（妇产科1994; 83：173-9）
Objective:To determine whether the quantitative and qualitative effects on lipoproteins differ between two doses of conjugated equine estrogen before and after progestin administration.Methods:We randomized 103 postmenopausal women into a control group and into two groups receiving either 0.625 mg or 1.25 mg of conjugated equine estrogen for 4 months and then the same estrogen dose plus cyclic medroxyprogesterone acetate for 8 months.Results:Both estrogen doses similarly lowered (P< 01) low-density lipoprotein (LDL) cholesterol and raised (P<. 01) high-density lipoprotein (HDL) cholesterol, apolipoprotein AI, triglyceride levels of all lipoproteins, and sex hormone-binding globulin capacity. Cyclic addition of the progestin reduced HDL cholesterol (P< 01) and apolipoprotein AI (P< 05), but not LDL cholesterol in either estrogen group. A greater lowering of HDL cholesterol (P< 05) in response to the progestin was seen with the 0.625-mg dose of estrogen. Estrogen-induced triglyceride enrichment of HDL and LDL was not reversed by the progestin.Conclusion:The only significant quantitative difference in lipoprotein levels between the doses of conjugated equine estrogen before or after administration of medroxyprogesterone acetate was a greater decline in HDL cholesterol levels with the lower dose after 4 months of the progestin. This difference was not sustained over time. There were no differences between doses in the estrogeninduced triglyceride enrichment of lipoproteins, and these qualitative changes were not affected by the progestin.(Obstet Gynecol 1994; 83: 173-9)