Persistence of anti-NGF induced dorsal root axons: possible penetration into the mammalian spinal cord.
Persistence of anti-NGF induced dorsal root axons: possible penetration into the mammalian spinal cord.
复制标题
抗 NGF 诱导的背根轴突的持续存在：可能渗透到哺乳动物脊髓中。
DOI：
10.1016/0006-8993(87)91078-x
复制
发表时间：
1987
期刊：
影响因子：
2.9
通讯作者：
Perez-Polo,JR
中科院分区：
文献类型：
--
作者：
Hulsebosch,CE;Coggeshall,RE;Perez-Polo,JR
新生大鼠每天注射神经生长因子蛋白（抗神经生长因子）的抗血清，持续1个月，然后再存活17个月。在抗NGF大鼠中测定背根神经节（DRG）中的神经元和背根（DR）中的轴突的数量，并与来自未处理的同窝仔的类似数量进行比较。我们发现，在抗神经生长因子大鼠中，背根节神经元数量减少了32%，有髓和无髓DR纤维分别增加了32%和34%。抗NGF大鼠的感觉细胞体平均比正常大鼠大23%。我们的结论是，在一个神经生长因子剥夺的环境中的DRG神经元的人口死亡，主要是小神经元，并在响应幸存的神经元发出额外的过程，持续大部分的生活的大鼠。这表明抗NGF诱导的轴突进入脊髓和突触。
Neonatal rats were given daily injections of antisera to nerve growth factor protein (anti-NGF) for a period of 1 month and then allowed to survive 17 more months. The number of neurons in dorsal root ganglia (DRG) and axons in the dorsal root (DR) were determined in the anti-NGF rats and compared to similar numbers from untreated littermates. We found a 32% decrease in DRG neuron number and 32 and 34% increases in myelinated and unmyelinated DR fibers, respectively, in the anti-NGF rats. The sensory cell bodies in the anti-NGF rats were on the average 23% larger than in the normal rats. We conclude that in an NGF deprived environment a population of DRG neurons dies, principally the small neurons, and in response the surviving neurons emit extra processes which persist for most of the life of the rat. This suggests that the anti-NGF induced axons enter the spinal cord and synapse.