The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
The prevalence of latent Mycobacterium tuberculosis infection based on an interferon-γ release assay: a cross-sectional survey among urban adults in Mwanza, Tanzania.
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DOI：
10.1371/journal.pone.0064008
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Andersen AB
中科院分区：
文献类型：
--
作者：
Jensen AV;Jensen L;Faurholt-Jepsen D;Aabye MG;Praygod G;Kidola J;Faurholt-Jepsen M;Changalucha J;Range N;Krarup H;Friis H;Andersen AB
据估计，世界上三分之一的人口潜伏感染结核分枝杆菌 (LTBI)。尽管低收入国家承受着世界上 LTBI 的最大负担，但在资源贫乏的结核病高流行国家（如坦桑尼亚）很少进行 LTBI 调查。主要目的是估计该国家城市环境中肺结核病例的家庭接触者和一组表面健康的社区对照者中 LTBI 的患病率。其次，我们通过定量邻近对照中急性期反应物：α-1-酸性糖蛋白（AGP）的循环水平来评估 LTBI 对炎症的潜在影响。该研究是在坦桑尼亚姆万扎结核病患者的两项营养研究的框架内进行的。家庭联系人和社区控制人员被邀请参加。该研究涉及问卷、BMI测定和血液样本以测量AGP、HIV检测和Quantiferon Gold In tube (QFN-IT)测试以检测LTBI迹象。 245 个家庭联系人和 192 个社区控制人员拥有可用的 QFN-IT 数据。在家庭接触者中，QFT-IT 阳性的比例为 59%，而邻里对照的比例为 41% (p = 0.001)。在针对性别、年龄、CD4 和 HIV 进行调整的线性回归模型中，与 QFT-IT 阴性检测的个体相比，QFT-IT 阳性检测与 α-1-酸性糖蛋白 (AGP) 水平升高 10% 相关（10B 1.10，95% CI 1.01；1.20，p = 0.03）。即使家庭中没有已知的结核病暴露情况，表面健康的城市坦桑尼亚人中 LTBI 也非常流行。研究发现 LTBI 与 AGP 水平升高有关。这一观察结果的意义值得进一步研究。
One third of the world’s population is estimated to be latently infected with Mycobacterium tuberculosis (LTBI). Surveys of LTBI are rarely performed in resource poor TB high endemic countries like Tanzania although low-income countries harbor the largest burden of the worlds LTBI. The primary objective was to estimate the prevalence of LTBI in household contacts of pulmonary TB cases and a group of apparently healthy neighborhood controls in an urban setting of such a country. Secondly we assessed potential impact of LTBI on inflammation by quantitating circulating levels of an acute phase reactant: alpha-1-acid glycoprotein (AGP) in neighborhood controls. The study was nested within the framework of two nutrition studies among TB patients in Mwanza, Tanzania. Household contacts- and neighborhood controls were invited to participate. The study involved a questionnaire, BMI determination and blood samples to measure AGP, HIV testing and a Quantiferon Gold In tube (QFN-IT) test to detect signs of LTBI. 245 household contacts and 192 neighborhood controls had available QFN-IT data. Among household contacts, the proportion of QFT-IT positive was 59% compared to 41% in the neighborhood controls (p = 0.001). In a linear regression model adjusted for sex, age, CD4 and HIV, a QFT-IT positive test was associated with a 10% higher level of alpha-1-acid glycoprotein(AGP) (10B 1.10, 95% CI 1.01; 1.20, p = 0.03), compared to individuals with a QFT-IT negative test. LTBI is highly prevalent among apparently healthy urban Tanzanians even without known exposure to TB in the household. LTBI was found to be associated with elevated levels of AGP. The implications of this observation merit further studies.
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